Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J Oral Pathol Med. 2013 Feb;42(2):125-32. doi: 10.1111/j.1600-0714.2012.01178.x. Epub 2012 May 29.
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) was found overexpressed in various cancer types suggesting its possible role in carcinogenesis. Analysis of IMP3 expression in head and neck squamous cell carcinomas (HNSCC) is rare so that we evaluated it using tissue microarray method.
Immunohistochemical analysis of IMP3 was performed on samples from over 400 patients. The expression was measured semiquantitative, subsequently divided into four categories (negative, weak, medium, or strong) and correlated with several available clinicopathologic parameters.
For HNSCC, positive IMP3 expression was observed in patients with all tumor stages (pT1-4) and nodal stages (pN0-3), showing also significant statistical correlation (P=0.023 and P=0.0013, respectively). No further correlations were found. Separate analysis according to tumor localization (oral cavity, oropharyngeal, and laryngeal) showed a significant correlation of positive IMP3 expression and overall survival (P=0.038) only in patients with tumors of the oral cavity. Multivariate analysis showed IMP3 as an independent predictive marker for oral squamous cell carcinomas (OSCC).
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression might be used as an independent prognostic factor in the subgroup of OSCC.
胰岛素样生长因子 II mRNA 结合蛋白 3（IMP3）在多种癌症类型中过表达，表明其在致癌作用中的可能作用。头颈部鳞状细胞癌（HNSCC）中 IMP3 表达的分析很少，因此我们使用组织微阵列方法进行了评估。
对超过 400 名患者的样本进行 IMP3 的免疫组织化学分析。通过半定量测量表达，随后将其分为四个类别（阴性、弱阳性、中等强度和强阳性），并与几个可用的临床病理参数相关联。
对于 HNSCC，IMP3 的阳性表达在所有肿瘤分期（pT1-4）和淋巴结分期（pN0-3）的患者中均可见，并显示出显著的统计学相关性（分别为 P=0.023 和 P=0.0013）。没有发现进一步的相关性。根据肿瘤定位（口腔、口咽和喉）进行的单独分析显示，IMP3 的阳性表达与总生存之间存在显著相关性（P=0.038），仅在口腔肿瘤患者中如此。多变量分析显示，IMP3 是口腔鳞状细胞癌（OSCC）的独立预测标志物。
胰岛素样生长因子 II mRNA 结合蛋白 3（IMP3）的表达可以作为 OSCC 亚组的独立预后因素。
