Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK.
BMJ Open. 2013 Apr 2;3(4). doi: 10.1136/bmjopen-2013-002766. Print 2013.
There is little awareness of venous thromboembolism (VTE) in the public arena. Most commonly known causes are-travellers' thrombosis and thrombosis associated with oral contraception, both frequently referred to in the media. However, VTE is a substantial healthcare problem, resulting in mortality, morbidity and economic cost. Most hospitalised patients have one or more risk factors for VTE. Around 60% of people undergoing hip or knee replacement will suffer a deep vein thrombosis without preventative intervention. Studies demonstrate a risk reduction for VTE of up to 70% with preventative medicine for medical and surgical conditions: cancer, orthopaedic surgery, general surgery and acutely ill medical admissions. Results will be used to identify methods of increasing knowledge of VTE prevention and for the development of educational and patient information materials.
A two-stage, mixed-method study using surveys with primary healthcare professionals and patients followed by interviews with primary healthcare professionals, patients, acute trusts and other relevant organisations. Survey and qualitative interview data will examine the current practice of thromboprophylaxis, and the knowledge and experience of VTE prevention for the development of education initiatives for primary healthcare professionals and patients to adopt thromboprophylaxis outside the hospital setting. As this is a scientific exploratory study for the generation, rather than testing, of new hypotheses a sample-size analysis is not called for. Survey data will be analysed using SPSS version 20. Open-ended responses will be analysed using qualitative thematic methods. The recorded and transcribed semistructured interview data will be analysed using constant comparative methods.
Ethics approval has been provided by the National Research Ethics Committee (reference: 11/H0605/5) and site-specific R&D approval granted by the relevant R&D National Health Service trusts. Findings will be disseminated at healthcare and academic conferences and written for peer-reviewed publication.
NIHR RP-PG-0608-10073.
公众对静脉血栓栓塞症（VTE）知之甚少。最常见的病因是旅行者血栓和与口服避孕药相关的血栓，这两种情况在媒体中经常被提及。然而，VTE 是一个严重的医疗保健问题，导致死亡率、发病率和经济成本。大多数住院患者都有一个或多个 VTE 风险因素。大约 60%接受髋关节或膝关节置换术的人在没有预防干预的情况下会患上深静脉血栓。研究表明，对于医疗和外科疾病：癌症、骨科手术、普通外科和急症住院患者，预防性药物可将 VTE 风险降低多达 70%。结果将用于确定提高 VTE 预防知识的方法，并为初级保健专业人员和患者开发教育和患者信息材料。
采用两阶段、混合方法研究，对初级保健专业人员和患者进行调查，然后对初级保健专业人员、患者、急症信托机构和其他相关组织进行访谈。调查和定性访谈数据将检查当前的血栓预防实践，以及 VTE 预防知识和经验，以制定初级保健专业人员和患者在医院环境之外采用血栓预防的教育计划。由于这是一项为生成新假设而不是测试新假设的科学探索性研究，因此不需要进行样本量分析。将使用 SPSS 版本 20 分析调查数据。将使用定性主题方法分析开放式回答。将使用恒定性比较方法分析记录和转录的半结构化访谈数据。
国家研究伦理委员会（参考号：11/H0605/5）已提供伦理批准，并且相关研发国家卫生服务信托机构已授予特定地点的研发批准。研究结果将在医疗保健和学术会议上发表，并为同行评审出版物撰写。
NIHR RP-PG-0608-10073。
