Pollak C P, Perlick D, Linsner J P, Wenston J, Hsieh F
Department of Psychiatry, New York Hospital-Cornell Medical Center, White Plains.
J Community Health. 1990 Apr;15(2):123-35. doi: 10.1007/BF01321316.
In 1984-85, 1855 elderly residents of an urban community responded to a comprehensive baseline interview that included questions regarding an extensive set of sleep characteristics and problems. During the subsequent 3 1/2 years of follow-up, 16.7% of the respondents died and 3.5% were placed in nursing homes. The predictive significance of each sleep characteristic for mortality and for nursing home placement was determined separately for males and females, using Cox proportional hazards models. Selected demographic and psychosocial variables were also entered into the models. Age, problems with activities of daily living (ADL), self-assessed health, income, cognitive impairment, depression and whether respondents were living alone were controlled for statistically. Of the many variables analyzed, in males insomnia was the strongest predictor of both mortality and nursing home placement. For mortality, the relative hazard associated with insomnia exceeded the hazards associated with age, ADL problems, fair-poor health and low income. For nursing home placement, the hazard associated with insomnia exceeded that associated with cognitive impairment. The relationships of insomnia to mortality and nursing home placement were U-shaped, with a worse outcome if insomnia complaints over the preceding 2 weeks were either prominent (numerous or frequent) or absent. For females, insomnia was a borderline predictor of mortality and did not predict nursing home placement at all. Symptoms of the restless legs syndrome predicted mortality for females in some Cox regression models. Reported sleep duration, symptoms of sleep apnea and frequent use of hypnotic drugs did not predict mortality or nursing home placement in either sex.
1984 - 1985年,一个城市社区的1855名老年居民接受了一次全面的基线访谈,其中包括一系列有关睡眠特征和问题的提问。在随后3年半的随访期间,16.7%的受访者死亡,3.5%的人被送进了养老院。使用Cox比例风险模型分别确定了男性和女性的每种睡眠特征对死亡率和养老院安置的预测意义。选定的人口统计学和社会心理变量也被纳入模型。对年龄、日常生活活动(ADL)问题、自我评估的健康状况、收入、认知障碍、抑郁以及受访者是否独居进行了统计学控制。在分析的众多变量中,男性的失眠是死亡率和养老院安置的最强预测因素。就死亡率而言,与失眠相关的相对风险超过了与年龄、ADL问题、健康状况一般或较差以及低收入相关的风险。就养老院安置而言,与失眠相关的风险超过了与认知障碍相关的风险。失眠与死亡率和养老院安置之间的关系呈U形,如果前两周的失眠主诉突出(数量多或频繁)或没有,则结果更差。对于女性来说,失眠是死亡率的临界预测因素,根本不能预测养老院安置情况。在一些Cox回归模型中,不安腿综合征的症状可预测女性的死亡率。报告的睡眠时间、睡眠呼吸暂停症状以及催眠药物的频繁使用在两性中均不能预测死亡率或养老院安置情况。