Inpp4b 是破骨细胞分化的新型负调节剂，也是人类骨质疏松症的一个预后基因座。
Inpp4b is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis.
机构信息
Clinical Research Institute of Montreal, Départment de Médecine, Université de Montréal, Department of Medicine, McGill University, Montréal, Québec, Canada.
出版信息
Ann N Y Acad Sci. 2013 Mar;1280:52-4. doi: 10.1111/nyas.12014.
PMID:23551105
Abstract
Inositol polyphosphate 4-phosphatase type II (Inpp4b) is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis. This short overview summarizes some of the cellular, molecular, and crosstalk signaling mechanisms that control osteoclast and osteoblast differentiation and activation.
摘要
肌醇多磷酸 4-磷酸酶 II 型（Inpp4b）是破骨细胞分化的新型负调节剂，也是人类骨质疏松症的预后基因座。本文简要概述了一些控制破骨细胞和骨细胞分化和激活的细胞、分子和串扰信号机制。
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