Khosravi Mohsen, Sheikhnia Farhad, Pashaei Mohammad Reza, Karimi-Dehkordi Maryam, Alizadeh-Fanalou Shahin
Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
J Cardiovasc Thorac Res. 2024;16(4):202-210. doi: 10.34172/jcvtr.33145. Epub 2024 Dec 23.
Cardiovascular disease (CVD) and atherosclerosis are major causes of mortality worldwide. Early and accurate diagnosis of vascular thickening by predictive markers can help reduce the death rate of these diseases. Low-density lipoprotein (LDL) particles, which are rich in cholesterol, are regarded as key biomarkers for CVD and atherosclerosis. Numerous studies have demonstrated that pattern B (small dense LDL, sdLDL) is more atherogenic than LDL and can serve as a superior quantitative marker for CVD than LDL. Furthermore, several studies have indicated that carotid intima-media thickness (cIMT) is a reliable marker for the early detection of CVD and atherosclerosis in various populations. This review examines the relationship between sdLDL concentration and cIMT. It is concluded that sdLDL concentration has a positive correlation with cIMT, and their combined use can facilitate a more precise assessment of the diseases, especially atherosclerosis.
心血管疾病（CVD）和动脉粥样硬化是全球主要的死亡原因。通过预测性标志物对血管增厚进行早期准确诊断有助于降低这些疾病的死亡率。富含胆固醇的低密度脂蛋白（LDL）颗粒被视为CVD和动脉粥样硬化的关键生物标志物。大量研究表明，B型（小而密LDL，sdLDL）比LDL更具致动脉粥样硬化性，并且可作为比LDL更优越的CVD定量标志物。此外，多项研究表明，颈动脉内膜中层厚度（cIMT）是在不同人群中早期检测CVD和动脉粥样硬化的可靠标志物。本综述探讨了sdLDL浓度与cIMT之间的关系。得出的结论是，sdLDL浓度与cIMT呈正相关，联合使用它们可以更精确地评估这些疾病，尤其是动脉粥样硬化。
