Rehman Abdul
Department of General Surgery, PAEC General Hospital, Islamabad.
J Coll Physicians Surg Pak. 2013 Apr;23(4):282-4.
Primary neuroendocrine carcinoma of the breast (NECB) is an extremely rare variant of breast cancer having aggressive clinicopathological behaviour and poor prognosis. A 62 years old woman presented with a painless lump in the left breast. Microscopic and immunohistochemical evaluation of the core-tissue biopsy and of the mastectomy specimen revealed moderately-differentiated neuroendocrine carcinoma of the breast. She was labeled as a case of primary neuroendocrine carcinoma of the breast after an infallible exclusion of any concomitant lesion elsewhere in the body. Modified radical mastectomy with level II axillary clearance, chemoradiotherapy and Famoxifen have led to an uneventful 5-year survival till the last follow-up.
乳腺原发性神经内分泌癌（NECB）是一种极为罕见的乳腺癌变体，具有侵袭性的临床病理行为和较差的预后。一名62岁女性因左乳出现无痛性肿块就诊。对核心组织活检和乳房切除标本进行显微镜检查及免疫组化评估，结果显示为乳腺中分化神经内分泌癌。在明确排除身体其他部位存在任何伴随病变后，她被诊断为乳腺原发性神经内分泌癌病例。采用改良根治性乳房切除术加II级腋窝清扫、放化疗及法莫昔芬治疗后，患者在最后一次随访时已顺利存活5年。
