Backman C, Boquist L, Fridén J, Lorentzon R, Toolanen G
Department of Hand and Plastic Surgery, University of Umeå, Sweden.
J Orthop Res. 1990 Jul;8(4):541-7. doi: 10.1002/jor.1100080410.
An experimental model for inducing chronic Achilles paratenonitis with tendinosis in the rabbit is presented. Thirteen rabbits were exercised in a kicking machine producing passive flexions and extensions of the ankle joint. Active contractions of the triceps surae muscles were induced by electric stimulation via surface electrodes. The animals were exercised for 5 to 6 weeks, with a rate of 150 flexions and extensions per minute for 2 h, three times a week. Light microscopic examination showed degenerative changes of the tendon, and increased number of capillaries, infiltrates of inflammatory cells, edema, and fibrosis in the paratenon. We conclude that chronic Achilles paratenonitis with tendinosis can be experimentally induced in a standardized manner in rabbits.
本文介绍了一种在兔身上诱导慢性跟腱腱周组织炎伴肌腱病的实验模型。13只兔子在踢腿机上进行锻炼，使踝关节被动屈伸。通过表面电极进行电刺激诱导腓肠肌主动收缩。动物每周锻炼3次，每次2小时，每分钟屈伸150次，持续5至6周。光镜检查显示肌腱有退行性改变，腱周组织中毛细血管数量增加、炎性细胞浸润、水肿和纤维化。我们得出结论，慢性跟腱腱周组织炎伴肌腱病可以在兔子身上以标准化方式通过实验诱导产生。
