Yang Pei-Chi, Clancy Colleen E
Department of Pharmacology, University of California Davis. Davis, CA 96516-5270, USA.
J Biomed Res. 2011 Mar;25(2):81-9. doi: 10.1016/S1674-8301(11)60010-9.
It has been observed that the incidence of heart failure and Brugada syndrome are higher in men, while women are more likely to have QT interval prolongation and develop torsades de pointes (TdP). Over the past decade, new studies have improved our understanding of the mechanisms of abnormal repolarization and the relationship between gender differences in cardiac repolarization and presentation of clinical syndromes. Nevertheless, the causes of gender-based differences in cardiac disease are still not completely clear. This review paper briefly summarized what is currently known about gender differences in heart failure, Brugada syndrome and long QT syndrome from molecular mechanisms to clinical presentations.
据观察，心力衰竭和 Brugada 综合征的发病率在男性中较高，而女性更易出现 QT 间期延长并发生尖端扭转型室速（TdP）。在过去十年中，新的研究增进了我们对复极异常机制以及心脏复极性别差异与临床综合征表现之间关系的理解。然而，心脏病基于性别的差异原因仍不完全清楚。这篇综述文章简要总结了目前已知的关于心力衰竭、Brugada 综合征和长 QT 综合征在分子机制至临床表现方面的性别差异。
