Department of Pediatrics, Emory University, Atlanta, GA, USA.
J Mol Cell Cardiol. 2010 Apr;48(4):619-32. doi: 10.1016/j.yjmcc.2010.01.009. Epub 2010 Jan 20.
Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying heart failure-associated arrhythmia are poorly understood. As a consequence, effectiveness of antiarrhythmic pharmacotherapy remains elusive. Here, we review recent advances in our understanding of heart failure-associated molecular events impacting the electrical function of the myocardium. We approach this from an anatomical standpoint, summarizing recent insights gleaned from pre-clinical models and discussing their relevance to human heart failure.
心力衰竭影响近 600 万美国人，每年新增病例达 50 万例。多达 50%的心衰患者死于心律失常，而心力衰竭相关心律失常的潜在机制尚不清楚。因此，抗心律失常药物治疗的效果仍难以捉摸。在这里，我们回顾了最近在理解影响心肌电功能的心力衰竭相关分子事件方面的进展。我们从解剖学的角度来探讨这个问题，总结了从临床前模型中获得的最新见解，并讨论了它们与人类心力衰竭的相关性。
