Niu Gang, Yu Xuewen, Yang Jian, Wang Rong, Zhang Shaojuan, Guo Youmin
Department of Diagnostic Radiology, the First Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
J Biomed Res. 2011 May;25(3):197-203. doi: 10.1016/S1674-8301(11)60026-2.
The aim of the present study was to compare the relationship of morphologically defined non-bulging/herniated, bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient (ADC). Thirty-two healthy volunteers and 28 patients with back pain or sciatica were examined by MRI. All intervertebral lumbar discs from L1 to S1 were classified according to morphological abnormality and degenerated grades. The ADC values of nucleus pulposus (NP) were measured and recorded. The significant differences about mean ADC values of NP were found between non-bulging/herniated discs and bulging discs as well as herniated discs (P < 0.05), whereas there were no significant differences in ADC values between bulging and herniated discs (P > 0.05). Moreover, statistically significant relationship was found in the mean ADC values of NP between "non-bulging/herniated and non-degenerated discs" and "non-bulging/herniated degenerated discs" as well as herniated discs (P < 0.05). Linear regression analysis between ADC value and disc level revealed an inverse correlation (r = -0.18). The ADC map of the NP is a potentially useful tool for the quantitative assessment of componential and molecular alterations accompanied with lumbar disc abnormalities.
本研究的目的是比较形态学定义的非膨出/非突出、膨出和突出的腰椎间盘与定量表观扩散系数（ADC）之间的关系。对32名健康志愿者和28名背痛或坐骨神经痛患者进行了MRI检查。根据形态学异常和退变程度对L1至S1的所有腰椎间盘进行分类。测量并记录髓核（NP）的ADC值。非膨出/非突出椎间盘与膨出椎间盘以及突出椎间盘之间的NP平均ADC值存在显著差异（P < 0.05），而膨出椎间盘与突出椎间盘之间的ADC值无显著差异（P > 0.05）。此外，“非膨出/非突出且未退变的椎间盘”与“非膨出/非突出退变的椎间盘”以及突出椎间盘之间的NP平均ADC值存在统计学显著关系（P < 0.05）。ADC值与椎间盘节段之间的线性回归分析显示呈负相关（r = -0.18）。NP的ADC图是定量评估伴有腰椎间盘异常的成分和分子改变的潜在有用工具。
