Wang Yaping, Song Yan, Suo Meng, Jin Xin, Tian Gang
Department of Cardiology, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
J Biomed Res. 2012 May;26(3):219-25. doi: 10.7555/JBR.26.20120013. Epub 2012 May 18.
We sought to investigate the effects of telmisartan on high-fat diet-induced hypertension and to explore the possible underlying mechanisms. Rats receiving high-fat diet were randomly divided into two groups, the telmisartan group (n = 9) and the high-fat diet group (n = 10). The control group consisted of age-matched rats on a regular diet (n = 10). At the end of the treatment, the body weight, blood pressure, insulin sensitivity and serum adiponectin levels of all rats were examined, and their visceral fat was extracted and weighed. Our results showed that telmisartan improved insulin resistance and dyslipidemia and increased serum adiponectin levels. Telmisartan also lowered both systolic blood pressure and diastolic blood pressure, and decreased the accumulation of perirenal fat associated with high-fat diet. Furthermore, telmisartan increased adiponectin mRNA expression in the perirenal fat. Correlation analysis showed that both systolic blood pressure and diastolic blood pressure were positively correlated with perirenal fat. These effects of telmisartan may be mediated through decreases in perirenal fat and contributed to the improvement of perirenal fat function. Our findings suggested a strong link between perirenal fat and high-fat diet-induced hypertension, and identified telmisartan as a potential drug for the treatment of obesity-related hypertension.
我们旨在研究替米沙坦对高脂饮食诱导的高血压的影响，并探讨其可能的潜在机制。接受高脂饮食的大鼠被随机分为两组，替米沙坦组（n = 9）和高脂饮食组（n = 10）。对照组由年龄匹配的正常饮食大鼠组成（n = 10）。治疗结束时，检测所有大鼠的体重、血压、胰岛素敏感性和血清脂联素水平，并提取和称量其内脏脂肪。我们的结果表明，替米沙坦改善了胰岛素抵抗和血脂异常，并提高了血清脂联素水平。替米沙坦还降低了收缩压和舒张压，并减少了与高脂饮食相关的肾周脂肪堆积。此外，替米沙坦增加了肾周脂肪中脂联素mRNA的表达。相关性分析表明，收缩压和舒张压均与肾周脂肪呈正相关。替米沙坦的这些作用可能是通过减少肾周脂肪介导的，并有助于改善肾周脂肪功能。我们的研究结果表明肾周脂肪与高脂饮食诱导的高血压之间存在密切联系，并确定替米沙坦为治疗肥胖相关高血压的潜在药物。
