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本文引用的文献

1
Stability analysis of ultrasound thick-shell contrast agents.超声厚壳造影剂的稳定性分析。
J Acoust Soc Am. 2012 Jan;131(1):24-34. doi: 10.1121/1.3666000.
2
Three-dimensional modeling of the dynamics of therapeutic ultrasound contrast agents.治疗超声对比剂动力学的三维建模。
Ultrasound Med Biol. 2010 Dec;36(12):2065-79. doi: 10.1016/j.ultrasmedbio.2010.08.022. Epub 2010 Oct 15.
3
Ultrasonic gene and drug delivery to the cardiovascular system.超声介导的基因和药物向心血管系统的递送。
Adv Drug Deliv Rev. 2008 Jun 30;60(10):1177-92. doi: 10.1016/j.addr.2008.03.004. Epub 2008 Apr 3.
4
Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery.超声微泡造影剂:基本原理及其在基因和药物递送中的应用
Annu Rev Biomed Eng. 2007;9:415-47. doi: 10.1146/annurev.bioeng.8.061505.095852.
5
Therapeutic effects of paclitaxel-containing ultrasound contrast agents.含紫杉醇的超声造影剂的治疗效果。
Ultrasound Med Biol. 2006 Nov;32(11):1771-80. doi: 10.1016/j.ultrasmedbio.2006.03.017.
6
Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.采用超声微泡破坏技术实现向胰岛的高效基因递送。
Proc Natl Acad Sci U S A. 2006 May 30;103(22):8469-74. doi: 10.1073/pnas.0602921103. Epub 2006 May 18.
7
Characterization of ultrasound contrast microbubbles using in vitro experiments and viscous and viscoelastic interface models for encapsulation.利用体外实验以及用于包封的粘性和粘弹性界面模型对超声造影微泡进行表征。
J Acoust Soc Am. 2005 Jul;118(1):539-50. doi: 10.1121/1.1923367.
8
Evaluation of gas-filled microparticles and sonoporation as gene delivery system: feasibility study in rodent tumor models.评估充气微粒和超声穿孔作为基因递送系统:在啮齿动物肿瘤模型中的可行性研究。
Radiology. 2005 Aug;236(2):572-8. doi: 10.1148/radiol.2362040870.
9
Resonance frequency of microbubbles: effect of viscosity.
J Acoust Soc Am. 2004 Sep;116(3):1463-73. doi: 10.1121/1.1778835.
10
Dynamics and fragmentation of thick-shelled microbubbles.厚壳微泡的动力学与破碎
IEEE Trans Ultrason Ferroelectr Freq Control. 2002 Oct;49(10):1400-10. doi: 10.1109/tuffc.2002.1041081.

有限厚度粘性壳微泡的超声破裂:简化零厚度壳模型。

Breakup of finite thickness viscous shell microbubbles by ultrasound: a simplified zero-thickness shell model.

机构信息

Dynaflow, Inc., 10621-J Iron Bridge Road, Jessup, Maryland 20794, USA.

出版信息

J Acoust Soc Am. 2013 Apr;133(4):1897-910. doi: 10.1121/1.4792492.

DOI:10.1121/1.4792492
PMID:23556560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4109778/
Abstract

A simplified three-dimensional (3-D) zero-thickness shell model was developed to recover the non-spherical response of thick-shelled encapsulated microbubbles subjected to ultrasound excitation. The model was validated by comparison with previously developed models and was then used to study the mechanism of bubble break-up during non-spherical deformations resulting from the presence of a nearby rigid boundary. The effects of the shell thickness and the bubble standoff distance from the solid wall on the bubble break-up were studied parametrically for a fixed insonification frequency and amplitude. A diagram of bubble shapes versus the normalized shell thickness and wall standoff was derived, and the potential bubble shapes at break-up from reentrant jets were categorized resulting in four distinct zones.

摘要

本文建立了一个简化的三维(3-D)零厚度壳模型,以恢复在超声激励下厚壳封装微泡的非球形响应。通过与之前开发的模型进行比较验证了模型的有效性,然后使用该模型研究了由于附近刚性边界的存在导致的非球形变形期间气泡破裂的机制。针对固定的激励频率和幅度,针对壳厚度和气泡与固壁的间隔距离对气泡破裂的影响进行了参数研究。得出了气泡形状与归一化壳厚度和壁间隔的关系图,并对再进入射流引起的潜在气泡破裂形状进行了分类,形成了四个不同的区域。