[深吸气对最大呼气流量（Vmax）的影响取决于年轻健康女性的基础支气管运动张力]

[Effect of deep inspiration on maximum expiratory flow (Vmax) depends on basal bronchomotor tone in young healthy females].

作者信息

Fujimura M, Nomura M, Sakamoto S, Kamio Y, Shibata K, Ogawa H, Nishi K, Matsuda T

机构信息

Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1990 Jan;28(1):105-12.

PMID:2355671

Abstract

The relationship between the effect of deep inspiration on Vmax and basal bronchomotor tone was studied by partial and maximum expiratory flow-volume curve in 16 young healthy females (20-21 years old). Effect of deep inspiration on Vmax (DI index; (PEF25-MEF25)/PEF25) significantly related to percent increase in PEF25 not only by inhalation of ipratropium bromide (r = 0.81, p less than 0.0002) but also by inhalation of salbutamol (r = -0.62, p less than 0.01). Furthermore, day to day variation of DI index significantly related to day to day variation of PEF25 (r = 0.68, p less than 0.005) but not to that of MEF25. These findings suggest that the bronchodilating effect of deep inspiration in young healthy females may depend on intensity of basal bronchomotor tone caused by tonic vagal nerve activity.

摘要

通过部分和最大呼气流量-容积曲线，对16名年轻健康女性（20 - 21岁）深吸气对Vmax和基础支气管运动张力的影响之间的关系进行了研究。深吸气对Vmax的影响（DI指数；(PEF25 - MEF25)/PEF25）不仅与吸入异丙托溴铵后PEF25的增加百分比显著相关（r = 0.81，p小于0.0002），而且与吸入沙丁胺醇后也显著相关（r = -0.62，p小于0.01）。此外，DI指数的每日变化与PEF25的每日变化显著相关（r = 0.68，p小于0.005），但与MEF25的每日变化无关。这些发现表明，年轻健康女性深吸气的支气管舒张作用可能取决于由迷走神经紧张性活动引起的基础支气管运动张力的强度。