具有可控方向性的三工位 DNA 连环旋转马达。
A three-station DNA catenane rotary motor with controlled directionality.
机构信息
Institute of Chemistry and The Minerva Center for Biohybrid Complex Systems, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
出版信息
Nano Lett. 2013 May 8;13(5):2303-8. doi: 10.1021/nl401010e. Epub 2013 Apr 10.
The assembly of DNA machines represents a central effort in DNA nanotechnology. We report on the first DNA rotor system composed of a two-ring catenane. The DNA rotor ring rotates in dictated directions along a wheel, and it occupies three distinct sites. Hg(2+)/cysteine or pH (H(+)/OH(-)) act as fuels or antifuels in positioning the rotor ring. Analysis of the kinetics reveals directional clockwise or anticlockwise population of the target-sites (>85%), and the rotor's direction is controlled by the shortest path on the wheel.
DNA 机器的组装代表了 DNA 纳米技术的核心努力。我们报告了第一个由两个环的索烃组成的 DNA 转子系统。DNA 转子环沿着轮子以规定的方向旋转，并占据三个不同的位置。Hg(2+)/半胱氨酸或 pH 值（H(+)/OH(-)）在定位转子环时充当燃料或反燃料。动力学分析表明目标位置的顺时针或逆时针种群具有明显的方向性（>85%），并且转子的方向由轮上的最短路径控制。
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