Altria Client Services Inc., 601 East Jackson Street, Richmond, VA 23219, USA.
Regul Toxicol Pharmacol. 2013 Jul;66(2):197-207. doi: 10.1016/j.yrtph.2013.03.013. Epub 2013 Apr 2.
This paper characterizes historical and current tobacco specific nitrosamine (TSNA) levels in mainstream (MS) cigarette smoke of US commercial cigarettes. To conduct this analysis, we gathered 35 years of published data of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN) levels in MS cigarette smoke. We also assessed internal data of MS smoke NNK and NNN levels generated from various market monitoring initiatives and from control cigarettes used in a multi-year program for testing cigarette ingredients. In all, we analyzed machine smoking data from 401 cigarette samples representing a wide range of products and design characteristics from multiple manufacturers and market leaders. There was no indication that TSNA levels systematically increased in cigarette MS smoke over the 35-year analysis period. In particular, TSNA levels expressed as either per cigarette or normalized for tar suggest a downward trend in MS smoke over the past 10 years. The apparent downward trend in TSNA levels in MS smoke may reflect industry and agricultural community efforts to reduce levels of TSNAs in tobacco and cigarette smoke.
本文描述了美国商业卷烟主流烟气中（MS）的历史和当前烟草特异性亚硝胺（TSNA）水平。为了进行这项分析，我们收集了 35 年来发表的 4-（甲基亚硝氨基）-1-（3-吡啶基）-1-丁酮（NNK）和 N-亚硝基降烟碱（NNN）在 MS 卷烟烟气中的水平数据。我们还评估了来自各种市场监测计划以及用于多年测试卷烟成分的对照卷烟的 MS 烟雾 NNK 和 NNN 水平的内部数据。总之，我们分析了来自 401 个卷烟样本的机器吸烟数据，这些样本代表了来自多个制造商和市场领导者的广泛产品和设计特点。在 35 年的分析期间，没有迹象表明 TSNA 水平在卷烟 MS 烟雾中系统地增加。特别是，以每支卷烟或按焦油标准化的 TSNA 水平表明，过去 10 年来 MS 烟雾中的 TSNA 水平呈下降趋势。MS 烟雾中 TSNA 水平的明显下降趋势可能反映了行业和农业社区为降低烟草和卷烟烟雾中 TSNA 水平所做的努力。
