Department of Infectious Diseases, University of Franche-Comté, UMR 6249, University Hospital, 25000 Besançon, France.
Eur J Clin Microbiol Infect Dis. 2013 Sep;32(9):1171-6. doi: 10.1007/s10096-013-1863-3. Epub 2013 Apr 6.
The proportion of group D streptococcal infective endocarditis (IE) (predominantly due to Streptococcus gallolyticus) and the incidence of colorectal cancer are higher in France than in most European countries. We assumed that this could be explained by a high group D streptococci (GDS) fecal carriage rate. The aims of this study were to re-assess the GDS fecal carriage rate in France and its relationship with colorectal cancer. Consecutive adult subjects who were to undergo a complete colonoscopy were invited to participate. GDS were searched in subjects' stools before their colonoscopy using biomolecular techniques. Colonoscopic findings were sorted into four subgroups: normal colonoscopy, non-tumoral lesions, benign tumors, and premalignant/malignant tumors. GDS fecal carriages were calculated overall and in each subgroup and compared. The data from 259 subjects were analyzed. GDS were identified in the feces of 12 subjects, with the following distribution: S. lutetiensis (n = 9), S. pasteurianus (n = 2), and S. gallolyticus (n = 1). This accounted for an overall GDS fecal carriage rate of 4.6 %. The GDS fecal carriage rate was 6 % in case of normal colonoscopy, 1.3 % in case of non-tumoral lesions, 3.2 % in case of benign tumors, and 11 % in case of premalignant/malignant tumors. These four percentages were not statistically different. The GDS fecal carriage rate was lower than expected, which did not confirm our working hypothesis. Most strains belonged to S. bovis biotype II, while S. gallolyticus was found only once. These findings suggest that different GDS play different roles in the etiopathogenesis of IE and colorectal cancer.
D 组链球菌（主要由牛链球菌引起）感染性心内膜炎（IE）和结直肠癌的比例在法国高于大多数欧洲国家。我们假设这可以用 D 组链球菌（GDS）粪便携带率高来解释。本研究的目的是重新评估法国 GDS 的粪便携带率及其与结直肠癌的关系。连续邀请要接受全结肠镜检查的成年受试者参加。使用生物分子技术在结肠镜检查前在受试者粪便中搜索 GDS。将结肠镜检查结果分为四个亚组：正常结肠镜检查、非肿瘤性病变、良性肿瘤和癌前/恶性肿瘤。总体和每个亚组计算 GDS 粪便携带率并进行比较。分析了 259 名受试者的数据。在 12 名受试者的粪便中鉴定出 GDS，分布如下：S. lutetiensis（n = 9）、S. pasteurianus（n = 2）和 S. gallolyticus（n = 1）。这占总 GDS 粪便携带率的 4.6%。正常结肠镜检查时 GDS 粪便携带率为 6%，非肿瘤性病变时为 1.3%，良性肿瘤时为 3.2%，癌前/恶性肿瘤时为 11%。这四个百分比没有统计学差异。GDS 粪便携带率低于预期，这与我们的工作假设不一致。大多数菌株属于 S. bovis 生物型 II，而仅发现一次 S. gallolyticus。这些发现表明，不同的 GDS 在 IE 和结直肠癌的发病机制中发挥不同的作用。
