蛋白包被纳米纤维促进 T 细胞活性。
Protein-coated nanofibers for promotion of T cell activity.
机构信息
The State Key Lab of Supramolecular Structure and Materials, Department of Chemistry, Jilin University, Changchun 130012, PR China.
出版信息
Chem Commun (Camb). 2013 May 11;49(38):3949-51. doi: 10.1039/c3cc41215f. Epub 2013 Apr 4.
PMID:23558380
Abstract
We have demonstrated that stable Concanavalin A (Con A)-coated supramolecular nanofibers can be constructed by complexation of self-assembled mannose nanofibers with Con A. The extended multivalent Con A nanofibers bind strongly to T cell surfaces and promote T cell activation.
摘要
我们已经证明，通过自组装的甘露糖纳米纤维与 Con A 的络合，可以构建稳定的伴刀豆球蛋白 A（Con A）涂层超分子纳米纤维。扩展的多价 Con A 纳米纤维与 T 细胞表面强烈结合，并促进 T 细胞活化。
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