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接受局限性近端胃切除术患者的长期预后。

Long-term outcomes of patients who underwent limited proximal gastrectomy.

机构信息

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan,

出版信息

Gastric Cancer. 2014 Jan;17(1):141-5. doi: 10.1007/s10120-013-0257-7. Epub 2013 Apr 5.

Abstract

BACKGROUND

Because the incidence of early gastric cancers has been increasing in Asian countries, postoperative quality of life has received considerable attention in addition to oncological outcomes.

METHODS

Eighty-four patients with clinically early gastric cancers were enrolled in this retrospective study. Among them, 35 patients underwent total gastrectomy (TG) and 49 patients underwent limited proximal gastrectomy (PG). Blood chemistry, changes in body weight, and oncological outcomes were compared between the two groups.

RESULTS

Postoperative hemoglobin levels and body weights were significantly lower in the TG group than in the PG group, and there were no significant differences in the levels of other nutritional indicators such as serum total protein and total cholesterol. However, the overall survival rates of patients in the PG group were similar to those of patients in the TG group (5-year survival rates, 95 versus 97 %, respectively; p = 0.86).

CONCLUSIONS

Limited proximal gastrectomy with regional lymph node dissection has possible positive effects on maintaining body weight and preventing postgastrectomy anemia with similar oncological outcomes to total gastrectomy in patients with early gastric cancers.

摘要

背景

由于亚洲国家早期胃癌的发病率不断增加,除了肿瘤学结果外,术后生活质量也受到了相当多的关注。

方法

本回顾性研究纳入了 84 例临床早期胃癌患者。其中 35 例患者接受全胃切除术(TG),49 例患者接受局限性近端胃切除术(PG)。比较两组患者的血液化学、体重变化和肿瘤学结果。

结果

TG 组术后血红蛋白和体重明显低于 PG 组,其他营养指标如血清总蛋白和总胆固醇水平无显著差异。然而,PG 组患者的总生存率与 TG 组患者相似(5 年生存率分别为 95%和 97%;p=0.86)。

结论

对于早期胃癌患者,与全胃切除术相比,局限性近端胃切除术加区域淋巴结清扫术可能对维持体重和预防术后贫血具有积极作用,同时也具有相似的肿瘤学结果。

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