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近端胃切除术后改良管状食管胃吻合术与双通道重建术的安全性及短期结局:一项倾向评分匹配分析

Safety and short‑term outcomes of a modified tubular esophagogastrostomy versus double tract reconstruction after proximal gastrectomy: a propensity score matching analysis.

作者信息

Zhang Chaoyang, Wang Kaixing, Zhang Zhidong, Zhao Xuefeng, Yao Bin, Zhang Weishuai

机构信息

The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Rd. Changan District, Shijiazhuang, 050011, China.

出版信息

BMC Cancer. 2025 May 21;25(1):908. doi: 10.1186/s12885-025-14284-9.

Abstract

OBJECTIVE

To comparatively evaluate the short-term clinical efficacy and quality of life (QoL) between modified tubular esophagogastrostomy (mTEG) and double tract reconstruction (DTR) following proximal gastrectomy (PG), aiming to establish evidence-based recommendations for reconstruction method selection.

METHODS

The mTEG technique involved three essential steps: 1) tubular reconstruction of gastric remnant, 2) 3-cm artificial gastric fornix creation, and 3) His angle sharpening with posterior mediastinal fixation. This retrospective study included 288 PG patients (2021-2024). Propensity score matching (1:1, caliper = 0.03) balanced baseline characteristics, and thirty-three matched pairs were analyzed. Outcomes encompassed operative metrics, postoperative complications (Clavien-Dindo ≥ II), nutritional status (prealbumin, albumin, hemoglobin, BMI at 1/3/6 months), and QoL (EORTC QLQ-STO22 at 6 months).

RESULTS

The mTEG group demonstrated shorter median operative time (163.7 vs 247.9 min, p < 0.001) and postoperative hospitalization (8.3 vs 9.9 days, p = 0.001). Intraoperative outcomes including blood loss and lymph node yield were comparable. Early complications (≤ 30 days) occurred exclusively in the DTR group (4 cases: 2 anastomotic leakage, 1chylous leakage and 1 pulmonary related). complication rates showed no statistical difference (p > 0.05). Endoscopic findings demonstrated comparable incidence of reflux esophagitis in Los Angeles Grade B or higher (11.1% vs 4.5%, p = 0.457). Nutritional parameters and QoL scores remained equivalent between groups at all timepoints (p > 0.05).

CONCLUSION

mTEG represents a technically optimized reconstruction method that achieves equivalent nutritional preservation and reflux prevention compared to DTR, while offering distinct advantages in surgical efficiency and postoperative recovery. These findings support mTEG as a viable reconstruction option for PG patients.

摘要

目的

比较评估近端胃切除术(PG)后改良管状食管胃吻合术(mTEG)与双通道重建术(DTR)的短期临床疗效和生活质量(QoL),旨在为重建方法的选择建立循证推荐。

方法

mTEG技术包括三个关键步骤:1)胃残端的管状重建;2)创建3厘米的人工胃穹窿;3)通过后纵隔固定锐化His角。这项回顾性研究纳入了288例PG患者(2021年至2024年)。倾向评分匹配(1:1,卡尺 = 0.03)平衡了基线特征,并对33对匹配病例进行了分析。结果包括手术指标、术后并发症(Clavien-Dindo≥II级)、营养状况(1/3/6个月时的前白蛋白、白蛋白、血红蛋白、BMI)和QoL(6个月时的EORTC QLQ-STO22)。

结果

mTEG组的中位手术时间较短(163.7分钟对247.9分钟,p < 0.001),术后住院时间也较短(8.3天对9.9天,p = 0.001)。包括失血和淋巴结收获量在内的术中结果相当。早期并发症(≤30天)仅发生在DTR组(4例:2例吻合口漏、1例乳糜漏和1例肺部相关并发症)。并发症发生率无统计学差异(p > 0.05)。内镜检查结果显示,洛杉矶B级或更高等级的反流性食管炎发生率相当(11.1%对4.5%,p = 0.457)。两组在所有时间点的营养参数和QoL评分均保持相当(p > 0.05)。

结论

mTEG是一种技术优化的重建方法,与DTR相比,在营养保留和反流预防方面效果相当,同时在手术效率和术后恢复方面具有明显优势。这些发现支持mTEG作为PG患者可行的重建选择。

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