Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-Gu, Daegu, 705-718, Korea.
Muscle Nerve. 2014 Jan;49(1):56-60. doi: 10.1002/mus.23863. Epub 2013 Sep 20.
We evaluated the effect of platelet-rich plasma (PRP) injection in a rabbit model of dextrose-induced median nerve injury.
New Zealand white rabbits (n = 15) were divided randomly into 3 groups. Three different regimens (group 1: 0.1 ml saline; group 2: 10% dextrose with PRP; group 3: 10% dextrose with saline) were injected within the carpal tunnel. Electrophysiological and histological findings were evaluated 12 weeks after the injection.
The mean median motor latency in group 3 was significantly longer than that in groups 1 and 2. The cross-sectional area of the median nerve and subsynovial connective tissue thickness in group 3 were significantly larger than those in groups 1 and 2.
PRP injection may be effective in controlling median nerve injury, as demonstrated by improvement in electrophysiological and histological findings 12 weeks after dextrose injection.
我们评估了富血小板血浆（PRP）注射对葡萄糖诱导的兔正中神经损伤模型的影响。
将新西兰白兔（n=15）随机分为 3 组。在腕管内注射 3 种不同的方案（组 1：0.1ml 生理盐水；组 2：含 PRP 的 10%葡萄糖；组 3：含生理盐水的 10%葡萄糖）。注射后 12 周评估电生理和组织学结果。
组 3 的正中运动潜伏期的平均值明显长于组 1 和组 2。组 3 的正中神经横截面积和滑膜下结缔组织厚度明显大于组 1 和组 2。
PRP 注射可能有效控制正中神经损伤，葡萄糖注射后 12 周电生理和组织学结果改善证明了这一点。
