Robinson L R, Nielsen V K
Division of Rehabilitation Medicine, University of Pittsburgh School of Medicine, PA.
Muscle Nerve. 1990 Apr;13(4):279-85. doi: 10.1002/mus.880130402.
We studied the effects of prolonged high-frequency stimulation in normal rat tail nerves. Nerves could conduct impulses at 50 Hz for 5 hours without complete conduction block. However, over time there was a significant decrease in amplitude and increase in latency of the compound nerve action potential (CNAP), which gradually became desynchronized. Changes were influenced by the frequency of stimulation. When stimulating over 30 minutes at 20, 50, 100, and 143 Hz the amplitude decreased to 89%, 79%, 67%, and 65% of baseline values, respectively, whereas the latency was only significantly increased at 100 and 143 Hz. All changes were reversible upon cessation of stimulation. Changes could not be attributed to focal block at the site of stimulation. These changes in the CNAP may reflect functional limitations of the axon membrane which may have pathophysiological implications for the study of neuropathies and focal nerve lesions.
我们研究了长时间高频刺激对正常大鼠尾神经的影响。神经能够在50赫兹下传导冲动5小时而无完全传导阻滞。然而，随着时间的推移，复合神经动作电位（CNAP）的幅度显著降低，潜伏期增加，且逐渐变得不同步。这些变化受刺激频率的影响。当以20、50、100和143赫兹刺激超过30分钟时，幅度分别降至基线值的89%、79%、67%和65%，而潜伏期仅在100和143赫兹时显著增加。停止刺激后，所有变化均可逆转。这些变化不能归因于刺激部位的局灶性阻滞。CNAP的这些变化可能反映了轴突膜的功能限制，这可能对神经病和局灶性神经病变的研究具有病理生理学意义。
