Andersen H, Nielsen J F, Nielsen V K
Department of Neurophysiology, Arhus University Hospital, Denmark.
Muscle Nerve. 1994 Jan;17(1):80-4. doi: 10.1002/mus.880170111.
The effect of insulin on the response to long-term high-frequency stimulation (HFS = 143 Hz for 20 min) was studied in mixed tail nerves of acute streptozotocin-induced diabetic rats. In consecutive tests, untreated diabetic rats showed a significant decrease in nerve conduction velocity (NCV) and peak-to-peak amplitude (P-Pamp) and the depression of the P-Pamp during HFS was augmented. In contrast, NCV and P-Pamp in the insulin-treated rats were unchanged from the prediabetic state, but the depression of the P-Pamp during HFS reached the same degree as in untreated rats. This implies that although insulin treatment of acute experimental diabetes is able to preserve a normal NCV and P-Pamp in the resting state, it is unable to preserve normal nerve function under stress produced by HFS. Monitoring of the axon membrane functional capacity may have clinical implications in the control of peripheral neuropathies.
在急性链脲佐菌素诱导的糖尿病大鼠的混合尾神经中，研究了胰岛素对长期高频刺激（HFS = 143 Hz，持续20分钟）反应的影响。在连续测试中，未经治疗的糖尿病大鼠神经传导速度（NCV）和峰峰值幅度（P-Pamp）显著降低，且HFS期间P-Pamp的抑制增强。相比之下，胰岛素治疗的大鼠的NCV和P-Pamp与糖尿病前期状态相比没有变化，但HFS期间P-Pamp的抑制程度与未经治疗的大鼠相同。这意味着，虽然胰岛素治疗急性实验性糖尿病能够在静息状态下保持正常的NCV和P-Pamp，但在HFS产生的应激下无法保持正常的神经功能。监测轴突膜功能能力可能对控制周围神经病变具有临床意义。
