Nielsen J F, Andersen H, Nielsen V K
Department of Neurophysiology, Arhus University Hospital, Denmark.
Muscle Nerve. 1993 Mar;16(3):283-8. doi: 10.1002/mus.880160307.
The effect of long-term (40 min) high frequency stimulation (143 Hz) of sensory-motor tail nerves was studied in normal and in streptozotocin-diabetic rats. The study comprised a 6-week period, repeating the test at 2-week intervals. In the initial (prediabetic) study, single experiments showed a mild depression of the peak-to-peak amplitude during high frequency stimulation, which reversed completely during a subsequent rest period. In normal rats, the amplitude depression was unchanged in repeated tests over a 6-week period. Diabetic rats showed a greater amplitude depression during high frequency stimulation. The difference was statistically significant after 2 weeks, but showed no further change at subsequent tests. The greater decrease in the amplitude in diabetic rats may reflect a depression of the axon membrane function, which may be the functional correlate to the inhibition of the Na/K ATPase activity in diabetes, described by others. Monitoring of the axon membrane functional capacity may have clinical implications in the control of peripheral neuropathies.
在正常大鼠和链脲佐菌素诱导的糖尿病大鼠中，研究了对感觉运动尾神经进行长期（40分钟）高频刺激（143赫兹）的效果。该研究为期6周，每隔2周重复进行测试。在最初的（糖尿病前期）研究中，单次实验显示高频刺激期间峰峰值幅度有轻度降低，在随后的休息期完全恢复。在正常大鼠中，在6周的重复测试中幅度降低没有变化。糖尿病大鼠在高频刺激期间显示出更大的幅度降低。2周后差异具有统计学意义，但在随后的测试中没有进一步变化。糖尿病大鼠幅度下降更大可能反映了轴突膜功能的抑制，这可能是其他人所描述的糖尿病中钠钾ATP酶活性抑制的功能相关因素。监测轴突膜功能能力可能对控制周围神经病变具有临床意义。
