• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age.围产期接触抗逆转录病毒核苷逆转录酶抑制剂会导致食蟹猴产生持续长达 3 年的遗传毒性。
J Infect Dis. 2013 Jul 15;208(2):244-8. doi: 10.1093/infdis/jit146. Epub 2013 Apr 4.
2
Mitochondrial compromise in 3-year old patas monkeys exposed in utero to human-equivalent antiretroviral therapies.子宫内暴露于等效人类抗逆转录病毒疗法的3岁派塔斯猴的线粒体损伤。
Environ Mol Mutagen. 2016 Aug;57(7):526-34. doi: 10.1002/em.22033. Epub 2016 Jul 25.
3
Fetal consequences of maternal antiretroviral nucleoside reverse transcriptase inhibitor use in human and nonhuman primate pregnancy.孕妇使用抗逆转录病毒核苷类逆转录酶抑制剂对人类和非人灵长类动物妊娠胎儿的影响。
Curr Opin Pediatr. 2015 Apr;27(2):233-9. doi: 10.1097/MOP.0000000000000193.
4
Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity.经胎盘暴露的人类和猴子新生儿显示出类似的核苷类逆转录酶抑制剂诱导的线粒体毒性证据。
Environ Mol Mutagen. 2007 Apr-May;48(3-4):201-9. doi: 10.1002/em.20201.
5
Transplacental genotoxicity of combined antiretroviral nucleoside analogue therapy in Erythrocebus patas monkeys.联合抗逆转录病毒核苷类似物疗法对赤猴的经胎盘遗传毒性
J Acquir Immune Defic Syndr. 2002 Apr 1;29(4):323-9. doi: 10.1097/00126334-200204010-00001.
6
Erythrocebus patas monkey offspring exposed perinatally to NRTIs sustain skeletal muscle mitochondrial compromise at birth and at 1 year of age.围产期暴露于核苷类逆转录酶抑制剂（NRTIs）的赤猴后代在出生时及1岁时存在骨骼肌线粒体损伤。
Toxicol Sci. 2007 Sep;99(1):203-13. doi: 10.1093/toxsci/kfm143. Epub 2007 Jun 1.
7
Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine.经胎盘暴露于齐多夫定加拉米夫定的胎猴红腹长尾猴的线粒体毒性。
AIDS Res Hum Retroviruses. 2004 Jan;20(1):91-100. doi: 10.1089/088922204322749530.
8
Progressive mitochondrial compromise in brains and livers of primates exposed in utero to nucleoside reverse transcriptase inhibitors (NRTIs).在子宫内暴露于核苷逆转录酶抑制剂 (NRTIs) 的灵长类动物的大脑和肝脏中进行性线粒体损伤。
Toxicol Sci. 2010 Nov;118(1):191-201. doi: 10.1093/toxsci/kfq235. Epub 2010 Aug 11.
9
Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis.通过液相色谱-串联质谱分析法测定齐多夫定与拉米夫定联合用药在成年赤猴体内的代谢及药代动力学。
Toxicol Appl Pharmacol. 2008 Jan 15;226(2):206-11. doi: 10.1016/j.taap.2007.09.007. Epub 2007 Sep 18.
10
Chronic stavudine exposure induces hepatic mitochondrial toxicity in adult Erythrocebus patas monkeys.长期接触司他夫定可诱导成年东非狒狒出现肝脏线粒体毒性。
J Hum Virol. 2001 Nov-Dec;4(6):335-42.

引用本文的文献

1
Cytogenetic changes in oral mucosal cells of human immunodeficiency virus-infected children and adolescents undergoing antiretroviral treatment.人类免疫缺陷病毒感染的儿童和青少年在接受抗逆转录病毒治疗时口腔黏膜细胞的细胞遗传学变化。
Rev Assoc Med Bras (1992). 2023 Sep 18;69(10):e20230397. doi: 10.1590/1806-9282.20230397. eCollection 2023.
2
Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants.胎儿代谢应激破坏免疫稳态并在暴露于1型人类免疫缺陷病毒和联合抗逆转录病毒疗法的婴儿中诱导促炎反应。
J Infect Dis. 2017 Aug 15;216(4):436-446. doi: 10.1093/infdis/jix291.
3
Mitochondrial compromise in 3-year old patas monkeys exposed in utero to human-equivalent antiretroviral therapies.子宫内暴露于等效人类抗逆转录病毒疗法的3岁派塔斯猴的线粒体损伤。
Environ Mol Mutagen. 2016 Aug;57(7):526-34. doi: 10.1002/em.22033. Epub 2016 Jul 25.
4
Use of Ciliogenesis to Detect Aneugens: The Role of Primary Cilia.利用纤毛发生检测非整倍体原：初级纤毛的作用。
Curr Protoc Toxicol. 2015 Nov 2;66:3.13.1-3.13.8. doi: 10.1002/0471140856.tx0313s66.
5
Fetal consequences of maternal antiretroviral nucleoside reverse transcriptase inhibitor use in human and nonhuman primate pregnancy.孕妇使用抗逆转录病毒核苷类逆转录酶抑制剂对人类和非人灵长类动物妊娠胎儿的影响。
Curr Opin Pediatr. 2015 Apr;27(2):233-9. doi: 10.1097/MOP.0000000000000193.
6
Comparing genotoxic signatures in cord blood cells from neonates exposed in utero to zidovudine or tenofovir.比较子宫内暴露于齐多夫定或替诺福韦的新生儿脐带血细胞中的基因毒性特征。
AIDS. 2015 Jul 17;29(11):1319-24. doi: 10.1097/QAD.0000000000000564.
7
Foetal loss and enhanced fertility observed in mice treated with Zidovudine or Nevirapine.用齐多夫定或奈韦拉平治疗的小鼠出现胎儿丢失和生育力增强的情况。
PLoS One. 2014 Sep 18;9(9):e107899. doi: 10.1371/journal.pone.0107899. eCollection 2014.
8
Selective protection of zidovudine-induced DNA-damage by the antioxidants WR-1065 and tempol.WR-1065 和 tempol 对叠氮胸苷诱导的 DNA 损伤的选择性保护作用。
Environ Mol Mutagen. 2014 Aug;55(7):566-72. doi: 10.1002/em.21872. Epub 2014 May 16.
9
Metabolic complications of in utero maternal HIV and antiretroviral exposure in HIV-exposed infants.子宫内母婴 HIV 暴露和抗逆转录病毒暴露对 HIV 暴露婴儿的代谢并发症。
Pediatr Infect Dis J. 2014 Jul;33(7):734-40. doi: 10.1097/INF.0000000000000224.
10
HIV-exposed uninfected children: a growing population with a vulnerable immune system?HIV 暴露但未感染的儿童：免疫系统脆弱的不断增长的人群？
Clin Exp Immunol. 2014 Apr;176(1):11-22. doi: 10.1111/cei.12251.

本文引用的文献

1
Genotoxic signature in cord blood cells of newborns exposed in utero to a Zidovudine-based antiretroviral combination.宫内暴露于齐多夫定为基础的抗逆转录病毒联合疗法的新生儿脐带血细胞中的遗传毒性特征。
J Infect Dis. 2013 Jul 15;208(2):235-43. doi: 10.1093/infdis/jit149. Epub 2013 Apr 4.
2
Progressive mitochondrial compromise in brains and livers of primates exposed in utero to nucleoside reverse transcriptase inhibitors (NRTIs).在子宫内暴露于核苷逆转录酶抑制剂 (NRTIs) 的灵长类动物的大脑和肝脏中进行性线粒体损伤。
Toxicol Sci. 2010 Nov;118(1):191-201. doi: 10.1093/toxsci/kfq235. Epub 2010 Aug 11.
3
Centrosomal amplification and aneuploidy induced by the antiretroviral drug AZT in hamster and human cells.抗逆转录病毒药物AZT在仓鼠和人类细胞中诱导的中心体扩增和非整倍体
Mutat Res. 2009 Jun 1;665(1-2):67-74. doi: 10.1016/j.mrfmmm.2009.03.004. Epub 2009 Mar 24.
4
Incidence of cancer in children perinatally exposed to nucleoside reverse transcriptase inhibitors.围产期暴露于核苷类逆转录酶抑制剂的儿童患癌发生率。
AIDS. 2008 Oct 18;22(16):2165-77. doi: 10.1097/QAD.0b013e328311d18b.
5
Metabolism and pharmacokinetics of the combination Zidovudine plus Lamivudine in the adult Erythrocebus patas monkey determined by liquid chromatography-tandem mass spectrometric analysis.通过液相色谱-串联质谱分析法测定齐多夫定与拉米夫定联合用药在成年赤猴体内的代谢及药代动力学。
Toxicol Appl Pharmacol. 2008 Jan 15;226(2):206-11. doi: 10.1016/j.taap.2007.09.007. Epub 2007 Sep 18.
6
Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV.为预防母婴传播艾滋病毒，在子宫内和产后接触齐多夫定的婴儿中，微核红细胞频率升高。
Environ Mol Mutagen. 2007 Apr-May;48(3-4):322-9. doi: 10.1002/em.20266.
7
Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC.在围产期用齐多夫定（AZT）以及齐多夫定与拉米夫定（3TC）联合治疗的p53单倍体缺陷小鼠中，次黄嘌呤磷酸核糖转移酶（Hprt）突变淋巴细胞和微核红细胞的频率
Environ Mol Mutagen. 2007 Apr-May;48(3-4):270-82. doi: 10.1002/em.20280.
8
Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC.通过彗星试验和GPA试验评估人类淋巴母细胞（H9）体外暴露或母婴对围产期暴露于齐多夫定或齐多夫定-拉米夫定后的遗传毒性。
Environ Mol Mutagen. 2007 Apr-May;48(3-4):330-43. doi: 10.1002/em.20285.
9
Transplacental carcinogenicity of 3'-azido-3'-deoxythymidine in B6C3F1 mice and F344 rats.3'-叠氮-3'-脱氧胸苷对B6C3F1小鼠和F344大鼠的经胎盘致癌性
Environ Mol Mutagen. 2007 Apr-May;48(3-4):283-98. doi: 10.1002/em.20297.
10
Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein.通过人类1型T细胞白血病病毒Tax癌蛋白靶向Ran结合蛋白-1导致细胞中中心体异常扩增。
Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18974-9. doi: 10.1073/pnas.0506659103. Epub 2005 Dec 19.

围产期接触抗逆转录病毒核苷逆转录酶抑制剂会导致食蟹猴产生持续长达 3 年的遗传毒性。

Perinatal exposure of patas monkeys to antiretroviral nucleoside reverse-transcriptase inhibitors induces genotoxicity persistent for up to 3 years of age.

机构信息

Carcinogen-DNA Interactions Section, Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892-4255, USA.

出版信息

J Infect Dis. 2013 Jul 15;208(2):244-8. doi: 10.1093/infdis/jit146. Epub 2013 Apr 4.

DOI:10.1093/infdis/jit146
PMID:23559463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3685224/
Abstract

BACKGROUND

Erythrocebus patas (patas) monkeys were used to model antiretroviral (ARV) drug in human immunodeficiency virus type 1-infected pregnant women.

METHODS

Pregnant patas dams were given human-equivalent doses of ARVs daily during 50% of gestation. Mesenchymal cells, cultured from bone marrow of patas offspring obtained at birth and at 1 and 3 years of age, were examined for genotoxicity, including centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes.

RESULTS

Compared with controls, statistically significant increases (P < .05) in centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes were found in mesenchymal cells from most groups of offspring at the 3 time points.

CONCLUSIONS

Transplacental nucleoside reverse-transcriptase inhibitor exposures induced fetal genotoxicity that was persistent for 3 years.

摘要

背景

食蟹猴（patas）被用于模拟人类免疫缺陷病毒 1 型感染孕妇的抗逆转录病毒（ARV）药物。

方法

在妊娠的 50%期间，给予妊娠食蟹猴每日给予相当于人类的 ARV 剂量。从出生和 1 岁和 3 岁时获得的食蟹猴后代的骨髓中培养间充质细胞，检查其遗传毒性，包括中心体扩增、微核和含有整条染色体的微核。

结果

与对照组相比，在 3 个时间点，来自大多数后代组的间充质细胞中，中心体扩增、微核和含有整条染色体的微核均有统计学意义的增加（P <.05）。

结论

胎盘核苷逆转录酶抑制剂暴露导致胎儿遗传毒性持续 3 年。