阿育吠陀经典配方五根宝丸对白化病大鼠的毒理学评价

Toxicological evaluation of Panchakola Avaleha, an Ayurvedic classical formulation, in albino rats.

作者信息

Singh Rajendra Kumar, Banerjee Rita, Upadhyay Sachhidananda, Mitra Achintya, Hazra Jayram

机构信息

Senior Research Fellow, National Research Institute of Ayurvedic Drug Development, Central Council for Research in Ayurvedic Sciences, Department of AYUSH, Ministry of Health and Family Welfare, Government of India, Kolkata, West Bengal, India.

出版信息

Ayu. 2012 Apr;33(2):303-6. doi: 10.4103/0974-8520.105257.

DOI:10.4103/0974-8520.105257

PMID:23559809

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3611640/

Abstract

The present study was carried out to assess the safety of standardized Panchakola Avaleha on albino rats (Wistar strain). Animals were administered three doses of Panchakola Avaleha by oral routes, viz. higher (500 mg/kg/day), middle (250 mg/kg/day), and therapeutic dose (50 mg/ kg/ day) for 28 consecutive days. Effects of the test drug on hematological, biochemical, and histopathologic parameters were evaluated. This study revealed normal behavior, no mortality, and no significant changes in hematological, biochemical, and histopathological examinations.

摘要

本研究旨在评估标准化五味甘露蜜膏对白化大鼠（Wistar品系）的安全性。通过口服途径给动物施用三剂五味甘露蜜膏，即高剂量（500毫克/千克/天）、中剂量（250毫克/千克/天）和治疗剂量（50毫克/千克/天），连续28天。评估了受试药物对血液学、生化和组织病理学参数的影响。本研究显示动物行为正常，无死亡，血液学、生化和组织病理学检查无显著变化。