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使用猪小肠黏膜下层神经引导通道促进大鼠周围神经再生。

Rat peripheral nerve regeneration using nerve guidance channel by porcine small intestinal submucosa.

作者信息

Yi Jin-Seok, Lee Hyung-Jin, Lee Hong-Jae, Lee Il-Woo, Yang Ji-Ho

机构信息

Department of Neurosurgery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.

出版信息

J Korean Neurosurg Soc. 2013 Feb;53(2):65-71. doi: 10.3340/jkns.2013.53.2.65. Epub 2013 Feb 28.

DOI:10.3340/jkns.2013.53.2.65
PMID:23560168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3611061/
Abstract

OBJECTIVE

In order to develop a novel nerve guidance channel using porcine small intestinal submucosa (SIS) for nerve regeneration, we investigated the possibility of SIS, a tissue consisting of acellular collagen material without cellular immunogenicity, and containing many kinds of growth factors, as a natural material with a new bioactive functionality.

METHODS

Left sciatic nerves were cut 5 mm in length, in 14 Sprague-Dawley rats. Grafts between the cut nerve ends were performed with a silicone tube (Silicon group, n=7) and rolled porcine SIS (SIS group, n=7). All rats underwent a motor function test and an electromyography (EMG) study on 4 and 10 weeks after grafting. After last EMG studies, the grafts, including proximal and distal nerve segments, were retrieved for histological analysis.

RESULTS

Foot ulcers, due to hypesthesia, were fewer in SIS group than in Silicon group. The run time tests for motor function study were 2.67 seconds in Silicon group and 5.92 seconds in SIS group. Rats in SIS group showed a better EMG response for distal motor latency and amplitude than in Silicon group. Histologically, all grafts contained some axons and myelination. However, the number of axons and the degree of myelination were significantly higher in SIS group than Silicon group.

CONCLUSION

These results show that the porcine SIS was an excellent option as a natural biomaterial for peripheral nerve regeneration since this material contains many kinds of nerve growth factors. Furthermore, it could be used as a biocompatible barrier covering neural tissue.

摘要

目的

为开发一种使用猪小肠黏膜下层（SIS）促进神经再生的新型神经导管，我们研究了SIS作为一种具有新生物活性功能的天然材料的可能性。SIS是一种由无细胞免疫原性的脱细胞胶原材料组成且含有多种生长因子的组织。

方法

在14只Sprague-Dawley大鼠中，将左侧坐骨神经切断5毫米。在切断的神经末端之间进行移植，分别使用硅胶管（硅胶组，n = 7）和卷状猪SIS（SIS组，n = 7）。所有大鼠在移植后4周和10周进行运动功能测试和肌电图（EMG）研究。在最后一次EMG研究后，取出包括近端和远端神经段的移植物进行组织学分析。

结果

由于感觉减退导致的足部溃疡，SIS组比硅胶组少。运动功能研究的跑步时间测试中，硅胶组为2.67秒，SIS组为5.92秒。SIS组大鼠在远端运动潜伏期和波幅方面的EMG反应比硅胶组更好。组织学上，所有移植物都含有一些轴突和髓鞘形成。然而，SIS组的轴突数量和髓鞘形成程度明显高于硅胶组。

结论

这些结果表明，猪SIS作为外周神经再生的天然生物材料是一个极佳选择，因为这种材料含有多种神经生长因子。此外，它可用作覆盖神经组织的生物相容性屏障。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/e9ab840ba06b/jkns-53-65-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/c7c1f189dc4e/jkns-53-65-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/f6952e8fd4ee/jkns-53-65-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/e2171c12d4c2/jkns-53-65-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/a2a11bdfb83f/jkns-53-65-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/76491884e842/jkns-53-65-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/f7844761163d/jkns-53-65-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/4efc2782dc84/jkns-53-65-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/e9ab840ba06b/jkns-53-65-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/c7c1f189dc4e/jkns-53-65-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/f6952e8fd4ee/jkns-53-65-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/e2171c12d4c2/jkns-53-65-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/a2a11bdfb83f/jkns-53-65-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/76491884e842/jkns-53-65-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/f7844761163d/jkns-53-65-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/4efc2782dc84/jkns-53-65-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4807/3611061/e9ab840ba06b/jkns-53-65-g008.jpg

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