用于组织工程应用的天然衍生生物材料。
Naturally-Derived Biomaterials for Tissue Engineering Applications.
机构信息
Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC, USA.
Health Research Institute of Aragón (IIS Aragón), Zaragoza, Spain.
出版信息
Adv Exp Med Biol. 2018;1077:421-449. doi: 10.1007/978-981-13-0947-2_23.
Abstract
Naturally-derived biomaterials have been used for decades in multiple regenerative medicine applications. From the simplest cell microcarriers made of collagen or alginate, to highly complex decellularized whole-organ scaffolds, these biomaterials represent a class of substances that is usually first in choice at the time of electing a functional and useful biomaterial. Hence, in this chapter we describe the several naturally-derived biomaterials used in tissue engineering applications and their classification, based on composition. We will also describe some of the present uses of the generated tissues like drug discovery, developmental biology, bioprinting and transplantation.
摘要
天然生物材料在多个再生医学应用中已经使用了几十年。从最简单的由胶原蛋白或藻酸盐制成的细胞微载体，到高度复杂的去细胞化整个器官支架，这些生物材料代表了一类物质，通常在选择功能性和有用的生物材料时首先考虑。因此，在本章中，我们将根据组成描述几种用于组织工程应用的天然生物材料及其分类。我们还将描述一些生成组织的当前用途，如药物发现、发育生物学、生物打印和移植。
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