Hsu Sheng-Yao, Chang Ming-Shien, Ko Mei-Lan, Harnod Tomor
Department of Ophthalmology, Tainan Municipal An-Nan Hospital-China Medical University, Tainan, Taiwan.
Clin Exp Optom. 2013 Jul;96(4):373-8. doi: 10.1111/cxo.12052. Epub 2013 Apr 8.
The retinal nerve fibre layer (RNFL) thickness is reportedly decreased in myopia; however, magnification adjustment is an important consideration when using optical coherence tomography (OCT) to evaluate myopic eyes. In this study, RNFL thickness and optic nerve head (ONH) size were measured in highly myopic eyes with and without magnification adjustments. The measurements were compared with magnification-adjusted OCT measurements of emmetropic control eyes.
In this cross-sectional study, RNFL thickness (global circle and quadrants) and ONH size (disc and rim areas) were measured in one eye of each of 70 participants with high myopia. Magnification-adjusted measurements taken in the high myopes were then compared with magnification-adjusted measurements taken in 70 emmetropic controls.
Comparisons of magnification-adjusted measurements between highly myopic and emmetropic control eyes showed that the highly myopic eyes had significantly thicker global and temporal RNFLs (p < 0.05), significantly thinner nasal RNFL (p < 0.05), and significantly larger disc and rim areas (p < 0.05). Superior and inferior RNFL thickness measurements did not differ significantly between the two groups (p > 0.05).
The OCT measurements obtained with magnification adjustment show global and temporal RNFL thicknesses and ONH size increase in highly myopic eyes.
据报道，近视患者的视网膜神经纤维层（RNFL）厚度会降低；然而，在使用光学相干断层扫描（OCT）评估近视眼时，放大倍数调整是一个重要的考虑因素。在本研究中，对有和没有进行放大倍数调整的高度近视眼测量了RNFL厚度和视神经乳头（ONH）大小。将这些测量结果与正视对照眼经放大倍数调整后的OCT测量结果进行比较。
在这项横断面研究中，对70名高度近视参与者的一只眼睛测量了RNFL厚度（全周和象限）和ONH大小（视盘和视盘边缘区域）。然后将高度近视眼中经放大倍数调整后的测量结果与70名正视对照者经放大倍数调整后的测量结果进行比较。
高度近视眼和正视对照眼经放大倍数调整后的测量结果比较显示，高度近视眼的全周和颞侧RNFL明显更厚（p < 0.05），鼻侧RNFL明显更薄（p < 0.05），视盘和视盘边缘区域明显更大（p < 0.05）。两组之间上、下RNFL厚度测量结果无显著差异（p > 0.05）。
经放大倍数调整后获得的OCT测量结果显示，高度近视眼的全周和颞侧RNFL厚度以及ONH大小增加。
