Duan Ming-Ming, Liu Hui, Zhong Yu-Lin
Department of ophthalmology, the First People's Hospital of Jiujiang City, Jiujiang, Jiangxi, China.
Department of ophthalmology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China.
Front Neurosci. 2023 Apr 6;17:1156990. doi: 10.3389/fnins.2023.1156990. eCollection 2023.
The purpose of this study was to study in retina thickness changes in myopic mice using optical coherence tomography (OCT).
There were 18 mice in the form-deprivation myopia (FDM) group，in which the left eye was not treated as a control;18 untreated mice served as a normal control group. The diopter of all mice was measured 21 days after birth (P21), before form deprivation. After 4 weeks of form deprivation (P49), the refraction, fundus, and retinal sublayer thickness of all mice were measured.
After 4 weeks of form deprivation, the refractive power of the right eye in the FDM group was significantly higher than that in the left eye ( < 0.05). There was no significant change in the refractive power of the left eye in the FDM group compared with the normal control group. The retina, nerve fiber layer (NFL), inner nuclear layer (INL), and outer nuclear layer (ONL) in the right eye of the FDM group were significantly thinner than those of both the FDM and control groups ( < 0.05). There was no significant change in photoreceptor (PR).
Our study highlights that the myopic mice have decreased R thickness, which might reflect the potential pathological mechanism of myopia.
本研究旨在使用光学相干断层扫描（OCT）研究近视小鼠视网膜厚度的变化。
形觉剥夺性近视（FDM）组有18只小鼠，其中左眼未处理作为对照；18只未处理的小鼠作为正常对照组。所有小鼠在出生后21天（P21），即形觉剥夺前测量屈光度。形觉剥夺4周后（P49），测量所有小鼠的屈光、眼底和视网膜各层厚度。
形觉剥夺4周后，FDM组右眼的屈光力明显高于左眼（<0.05）。FDM组左眼的屈光力与正常对照组相比无明显变化。FDM组右眼的视网膜、神经纤维层（NFL）、内核层（INL）和外核层（ONL）明显比FDM组和对照组的薄（<0.05）。光感受器（PR）无明显变化。
我们的研究强调近视小鼠的视网膜厚度降低，这可能反映了近视的潜在病理机制。
