Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Alzheimers Dement. 2014 Jan;10(1):62-6. doi: 10.1016/j.jalz.2013.01.006. Epub 2013 Apr 3.
Microbleeds have been associated with Alzheimer's disease (AD), although it is unclear whether they occur in atypical presentations of AD, such as the logopenic variant of primary progressive aphasia (lvPPA). We aimed to assess the presence and clinical correlates of microbleeds in lvPPA.
Thirteen lvPPA subjects underwent 3T T2*-weighted and fluid-attenuated inversion recovery magnetic resonance imaging and Pittsburgh compound B (PiB) positron emission tomography imaging. Microbleeds were identified on manual review and assigned a regional location. Total and regional white matter hyperintensity (WMH) burden was measured.
Microbleeds were observed in four lvPPA subjects (31%), most commonly in the frontal lobe. Subjects with microbleeds were older, more likely female, and had a greater burden of WMH than those without microbleeds. The regional distribution of microbleeds did not match the regional distribution of WMH. All cases were PiB positive.
Microbleeds occur in approximately one third of subjects with lvPPA, with older women at the highest risk.
微出血与阿尔茨海默病(AD)有关,尽管尚不清楚它们是否出现在 AD 的非典型表现中,例如原发性进行性失语症的失语法变异型(lvPPA)。我们旨在评估 lvPPA 中微出血的存在及其临床相关性。
13 名 lvPPA 受试者接受了 3T T2*-加权和液体衰减反转恢复磁共振成像和匹兹堡化合物 B(PiB)正电子发射断层扫描成像。通过手动审查识别微出血,并分配区域位置。测量总白质高信号(WMH)和区域 WMH 负担。
4 名 lvPPA 受试者(31%)观察到微出血,最常见于额叶。有微出血的受试者比没有微出血的受试者年龄更大,女性更多,WMH 负担更重。微出血的区域分布与 WMH 的区域分布不匹配。所有病例均为 PiB 阳性。
约三分之一的 lvPPA 受试者出现微出血,年龄较大的女性风险最高。