Departments of Psychiatry and Neurology, College of Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Alzheimers Dement. 2013 Sep;9(5):602-8. doi: 10.1016/j.jalz.2012.12.001. Epub 2013 Apr 3.
Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. This has been known since Dr. Alois Alzheimer's first case, Frau Auguste D., presented with emotional distress and delusions of infidelity/excessive jealousy, followed by cognitive symptoms. Being cognizant of this, in 2010 the Alzheimer's Association convened a research roundtable on the topic of NPS in AD. A major outcome of the roundtable was the founding of a Professional Interest Area (PIA) within the International Society to Advance Alzheimer's Research and Treatment (ISTAART). The NPS-PIA has prepared a series of documents that are intended to summarize the literature and provide more detailed specific recommendations for NPS research. This overview paper is the first of these living documents that will be updated periodically as the science advances. The overview is followed by syndrome-specific synthetic reviews and recommendations prepared by NPS-PIA workgroups on depression, apathy, sleep, agitation, and psychosis.
神经精神症状(NPS)在阿尔茨海默病(AD)中广泛存在且具有致残性。这自 Alois Alzheimer 博士的第一个病例 Frau Auguste D. 以来就已经为人所知,她表现出情绪困扰和不贞/过度嫉妒的妄想,随后出现认知症状。鉴于此,阿尔茨海默病协会于 2010 年就 AD 中的 NPS 问题召开了一次研究圆桌会议。圆桌会议的一个主要成果是在国际推进阿尔茨海默病研究和治疗协会(ISTAART)内成立了一个专业利益领域(PIA)。NPS-PIA 准备了一系列文件,旨在总结文献并为 NPS 研究提供更详细的具体建议。本综述论文是这些现有文件中的第一篇,随着科学的进步,将定期更新。概述之后是 NPS-PIA 工作组就抑郁症、冷漠、睡眠、激越和精神病制作的特定综合征综合评论和建议。