Department of Psychiatry, The Johns Hopkins Bayview, Baltimore, MD, USA.
Alzheimers Dement. 2011 Sep;7(5):532-9. doi: 10.1016/j.jalz.2011.05.2410.
Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related dementias. Once thought to emerge primarily in people with late-stage disease, these symptoms are currently known to manifest commonly in very early disease and in prodromal phases, such as mild cognitive impairment. Despite decades of research, reliable treatments for dementia-associated NPS have not been found, and those that are in widespread use present notable risks for people using these medications. An Alzheimer's Association Research Roundtable was convened in the spring of 2010 to review what is known about NPS in Alzheimer's disease, to discuss classification and underlying neuropathogenesis and vulnerabilities, and to formulate recommendations for new approaches to tailored therapeutics.
神经精神症状（NPS）是阿尔茨海默病和相关痴呆的核心特征。这些症状曾经被认为主要出现在疾病晚期的患者中，但目前已知它们在疾病的早期和前驱阶段（如轻度认知障碍）也很常见。尽管已经进行了数十年的研究，但仍未找到针对与痴呆相关的 NPS 的可靠治疗方法，而那些广泛使用的治疗方法对使用这些药物的人存在显著风险。为了审查阿尔茨海默病中 NPS 的已知情况，讨论分类和潜在的神经病理学发病机制和脆弱性，并为量身定制治疗方法的新方法制定建议，阿尔茨海默病协会研究圆桌会议于 2010 年春季召开。
