Groysman Tatyana, Rothfleisch Jeremy, Baldassano Marisa F
Department of Dermatology, Lehigh Valley Hospital, Allentown, PA 18103, USA.
Am J Dermatopathol. 2013 Jun;35(4):491-3. doi: 10.1097/DAD.0b013e31827439c7.
Circumscribed palmar or plantar hypokeratosis was first described by Pérez et al in 2002 as a unique entity of the skin in which they reported 10 patients who presented with well-circumscribed areas of erythematous depressed or eroded skin mostly over the thenar or hypothenar eminences of the palms and less commonly on the soles. Histologically, the lesions demonstrated an abrupt drop-off in the cornified layer resulting in a broad area of hypokeratosis. Pérez et al hypothesized that these lesions were a distinctive epidermal malformation. There have been several reports since, some of which implicate trauma as an etiologic agent; however, the exact etiology remains unclear. The authors present the first case of circumscribed palmar or plantar hypokeratosis on a nonacral site (chest of a 63-year-old man) with novel histological features, including granular parakeratosis and evidence of trauma (subepidermal fibrin and ulcerations).
局限性掌跖角化不全最早由佩雷斯等人于2002年描述为一种独特的皮肤病变，他们报告了10例患者，这些患者的手掌鱼际或小鱼际隆起处出现边界清晰的红斑性凹陷或糜烂皮肤区域，较少见于足底。组织学上，病变显示角质层突然变薄，导致广泛的角化不全区域。佩雷斯等人推测这些病变是一种独特的表皮畸形。此后有几篇报道，其中一些认为创伤是病因；然而，确切病因仍不清楚。作者报告了第一例发生在非肢端部位（一名63岁男性的胸部）的局限性掌跖角化不全病例，具有新的组织学特征，包括颗粒状不全角化及创伤证据（表皮下纤维蛋白和溃疡）。
