Yeh S Y
J Pharmacol Exp Ther. 1975 Jan;192(1):201-10.
Morphine, morphine glucuronide, morphine ethereal sulfate, normorphine and total normorphine in three consecutive 24-hour urines of four morphine-dependent subjects receiving morphine sulfate 60 mg s.c. q.i.d. have been determined with thin-layer chromatography and gas-liquid chromatography. With thin-layer chromatography the mean daily excretion of free morphine was 10% of the administered dose; morphine glucuronide, 65%; total (free and acid hydrolyzable conjugate) morphine 85%; and total normorphine, 3.5%. With gas-liquid chromatography, the percentage excretion for free morphine was 10%; total morphine, 74%; free normorphine, 1%; and total normorphine, 4%. The excretion of total drug was linearly related to the volume of the daily urine output.
对4名接受皮下注射硫酸吗啡60毫克、每日4次的吗啡依赖者连续3天的24小时尿液中的吗啡、吗啡葡糖苷酸、硫酸吗啡乙酯、去甲吗啡及总去甲吗啡，用薄层色谱法和气液色谱法进行了测定。用薄层色谱法测得，游离吗啡的平均日排泄量为给药剂量的10%；吗啡葡糖苷酸为65%；总（游离和酸可水解结合物）吗啡为85%；总去甲吗啡为3.5%。用气液色谱法测得，游离吗啡的排泄百分比为10%；总吗啡为74%；游离去甲吗啡为1%；总去甲吗啡为4%。药物的总排泄量与每日尿量呈线性关系。
