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tRNA 5' 端衍生的小 RNA 可以抑制人细胞中的蛋白质翻译。

Small RNAs derived from the 5' end of tRNA can inhibit protein translation in human cells.

机构信息

Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee, UK.

出版信息

RNA Biol. 2013 Apr;10(4):553-63. doi: 10.4161/rna.24285. Epub 2013 Apr 1.

DOI:10.4161/rna.24285
PMID:23563448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3710361/
Abstract

Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5' and 3' termini. To date, the function of these tRNA fragments (tRFs) derived from the 5' end of tRNA has not been investigated in depth. We present evidence that conserved residues in tRNA, present in all 5' tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA. These results implicate 5' tRFs in a new mechanism of gene regulation by small RNAs in human cells.

摘要

最近已经表明，tRNA 分子可以被加工成来自 5' 和 3' 末端的小 RNA。迄今为止，尚未深入研究这些来自 tRNA 5' 端的 tRNA 片段 (tRFs) 的功能。我们提出的证据表明，tRNA 中的保守残基存在于所有 5' tRFs 中，可以抑制蛋白质翻译过程，而不需要在 mRNA 中存在互补的靶位点。这些结果表明，5' tRFs 参与了人类细胞中小 RNA 调控基因的新机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/b4dcecd5fa56/rna-10-553-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/d7bf6ac485a5/rna-10-553-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/fd243160d9bb/rna-10-553-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/fc9be5277493/rna-10-553-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/fcf999069c13/rna-10-553-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/eb2ba18fea03/rna-10-553-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/3286e35fbbd0/rna-10-553-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/22286541f3b1/rna-10-553-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/b4dcecd5fa56/rna-10-553-g8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/d7bf6ac485a5/rna-10-553-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/fd243160d9bb/rna-10-553-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/fc9be5277493/rna-10-553-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/fcf999069c13/rna-10-553-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/eb2ba18fea03/rna-10-553-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/3286e35fbbd0/rna-10-553-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/22286541f3b1/rna-10-553-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bde/3710361/b4dcecd5fa56/rna-10-553-g8.jpg

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