雄激素剥夺疗法对复发性前列腺癌胆碱 PET/CT 的影响。
Influence of androgen deprivation therapy on choline PET/CT in recurrent prostate cancer.
机构信息
Department of Urology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
出版信息
Eur J Nucl Med Mol Imaging. 2013 Jul;40 Suppl 1:S41-7. doi: 10.1007/s00259-013-2398-7. Epub 2013 Apr 6.
PURPOSE
Recurrent prostate cancer is usually treated by combining radiotherapy and androgen deprivation therapy. To stage the cancer, choline positron emission tomography (PET)/CT can be performed. It is generally thought that androgen deprivation therapy does not influence choline PET/CT. In this article we focus on the molecular backgrounds of choline and androgens, and the results of preclinical and clinical studies performed using PET/CT.
METHODS
Using PubMed, we looked for the relevant articles about androgen deprivation therapy and choline PET/CT.
RESULTS
During ADT, a tendency of decreased uptake of choline in prostate cancer was observed, in particular in hormone-naïve patients.
CONCLUSION
We conclude that in order to prevent false-negative choline PET/CT scans androgen deprivation should be withheld prior to scanning, especially in hormone-naïve patients.
目的
复发性前列腺癌通常通过放射治疗和雄激素剥夺疗法联合治疗。为了对癌症进行分期，可以进行胆碱正电子发射断层扫描（PET）/CT 检查。一般认为雄激素剥夺疗法不会影响胆碱 PET/CT。在本文中，我们重点介绍了胆碱和雄激素的分子背景，以及使用 PET/CT 进行的临床前和临床研究结果。
方法
使用 PubMed，我们搜索了有关雄激素剥夺疗法和胆碱 PET/CT 的相关文章。
结果
在 ADT 期间，观察到前列腺癌中胆碱摄取的趋势下降，特别是在激素初治患者中。
结论
我们的结论是，为了防止胆碱 PET/CT 扫描出现假阴性，在扫描前应停止雄激素剥夺治疗，尤其是在激素初治患者中。
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