Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 200030 Shanghai, China.
J Mol Neurosci. 2013 Jun;50(2):353-9. doi: 10.1007/s12031-013-9995-6. Epub 2013 Apr 7.
Obsessive-compulsive disorder (OCD) is a common and severe mental illness, and its etiology still remains unknown. The glutamate transporter gene solute carrier family 1, member 1 was previously tested as a promising candidate for OCD by several research groups. However, subsequent studies were not consistent. OCD is a heterogeneous disease. Early-onset OCD is a demographically and clinically distinct subtype of OCD and may be a more homogeneous subtype. Gender-matched 244 early-onset OCD patients, 244 late-onset OCD patients, and 244 healthy controls were genotyped with four SNPs (rs10491734, rs2228622, rs301430, and rs301443) through TaqMan SNP genotyping assays. There were statistical differences in allele and genotype frequencies of rs10491734 in early-onset OCD patients compared to late-onset OCD or control subjects. The haplotype analysis showed that the four-locus haplotype (A-A-C-C and A-G-C-C) were associated with early onset obsessive-compulsive disorder after Bonferroni correction. The present study provided suggestive evidence that the rs10491734 was significantly associated with early-onset OCD in the Han Chinese population. However, these findings need further replication.
强迫症（OCD）是一种常见且严重的精神疾病，其病因仍不清楚。谷氨酸转运体基因溶质载体家族 1，成员 1 先前被几个研究小组测试为 OCD 的有希望的候选基因。然而，随后的研究并不一致。OCD 是一种异质性疾病。早发性 OCD 是一种在人口统计学和临床上有明显区别的 OCD 亚型，可能是一种更同质的亚型。对 244 名早发性 OCD 患者、244 名晚发性 OCD 患者和 244 名健康对照者进行了四个单核苷酸多态性（rs10491734、rs2228622、rs301430 和 rs301443）的 TaqMan SNP 基因分型检测。与晚发性 OCD 或对照组相比，早发性 OCD 患者在 rs10491734 的等位基因和基因型频率上存在统计学差异。连锁不平衡分析表明，经过 Bonferroni 校正后，四个位点的单体型（A-A-C-C 和 A-G-C-C）与早发性强迫症有关。本研究提供了提示性证据，表明 rs10491734 与汉族人群的早发性 OCD 显著相关。然而，这些发现需要进一步复制。
