戊型肝炎病毒的分子病毒学。
Molecular virology of hepatitis E virus.
机构信息
Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India.
出版信息
Semin Liver Dis. 2013 Feb;33(1):3-14. doi: 10.1055/s-0033-1338110. Epub 2013 Apr 5.
Hepatitis E virus (HEV) is the causative agent of hepatitis E. It is a nonenveloped virus with a ∼7.2 kilobases positive-stranded RNA genome. The molecular virology of HEV is getting better understood with the development of replicons and in vitro infection systems, and the discovery of related viruses that infect animal species other than humans. This review focuses on the virology of HEV and updates the current knowledge on the HEV genome and its constituent proteins--ORF1, ORF2, and ORF3, and the viral life cycle.
戊型肝炎病毒（HEV）是戊型肝炎的病原体。它是一种无包膜病毒，具有约 7.2kb 的正链 RNA 基因组。随着复制子和体外感染系统的发展，以及发现感染人类以外动物物种的相关病毒，HEV 的分子病毒学得到了更好的理解。这篇综述重点介绍了 HEV 的病毒学，并更新了关于 HEV 基因组及其组成蛋白——ORF1、ORF2 和 ORF3 以及病毒生命周期的最新知识。
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