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pH 控制的纳米颗粒递送至肿瘤细胞。

pH-controlled delivery of nanoparticles into tumor cells.

机构信息

Key Laboratory of Smart Drug Delivery, Ministry of Education& PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.

出版信息

Adv Healthc Mater. 2013 Nov;2(11):1435-9. doi: 10.1002/adhm.201300013. Epub 2013 Apr 8.

DOI:10.1002/adhm.201300013
PMID:23564477
Abstract

Nanoparticles target tumor cells by pH-controlled means. Nanoparticles carry three synergistic delivery functions: 1) tumor tissue targeting by the EPR effect; 2) tumor cell targeting by pHLIP-mediated membrane-localization; and 3) tumor cell uptake by adsorptive-mediated endocytosis.

摘要

纳米颗粒通过 pH 控制的方式靶向肿瘤细胞。纳米颗粒具有三种协同的递药功能：1）通过 EPR 效应实现肿瘤组织靶向；2）通过 pHLIP 介导的膜定位实现肿瘤细胞靶向；3）通过吸附介导的内吞作用实现肿瘤细胞摄取。

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