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铁过载会导致肝脏非实质细胞中 Bmp6 的表达，而不依赖于 BMP 信号通路。

Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway.

机构信息

Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR, USA.

出版信息

PLoS One. 2013;8(4):e60534. doi: 10.1371/journal.pone.0060534. Epub 2013 Apr 2.

DOI:10.1371/journal.pone.0060534
PMID:23565256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3615098/
Abstract

Bone morphogenetic protein 6 (BMP6) is an essential cytokine for the expression of hepcidin, an iron regulatory hormone secreted predominantly by hepatocytes. Bmp6 expression is upregulated by increased iron-levels in the liver. Both hepatocytes and non-parenchymal liver cells have detectable Bmp6 mRNA. Here we showed that induction of hepcidin expression in hepatocytes by dietary iron is associated with an elevation of Bmp6 mRNA in the non-parenchymal cells of the liver. Consistently, incubation with iron-saturated transferrin induces Bmp6 mRNA expression in isolated hepatic stellate cells, but not in hepatocytes. These observations suggest an important role of the non-parenchymal liver cells in regulating iron-homeostasis by acting as a source of Bmp6.

摘要

骨形态发生蛋白 6（BMP6）是铁调节激素——主要由肝细胞分泌的促红细胞生成素表达所必需的细胞因子。Bmp6 的表达受肝脏中铁含量增加的上调。肝细胞和非实质细胞肝脏均有可检测到的 Bmp6 mRNA。在这里，我们表明，膳食铁诱导肝细胞中促红细胞生成素的表达与非实质细胞中 Bmp6 mRNA 的升高有关。一致地，用铁饱和转铁蛋白孵育诱导分离的肝星状细胞中 Bmp6 mRNA 的表达，但在肝细胞中不诱导。这些观察结果表明，非实质细胞在通过充当 Bmp6 的来源来调节铁稳态方面发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/f55d863cb179/pone.0060534.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/d98c5149fa8e/pone.0060534.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/53979ad45ca9/pone.0060534.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/95a9f4a1e11e/pone.0060534.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/f55d863cb179/pone.0060534.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/d98c5149fa8e/pone.0060534.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/53979ad45ca9/pone.0060534.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/95a9f4a1e11e/pone.0060534.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a1c/3615098/f55d863cb179/pone.0060534.g004.jpg

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