Kiyak M V, Yesilada A K, Sevim K Z, Usta U
Department of of Plastic and Reconstructive Surgery, Sisli Etfal Research and Training Hospital, Istanbul, Turkey.
Acta Chir Plast. 2012;54(2):59-61.
Malignant melanoma is an aggressive tumor of melanocytes whose primary function is producing melanin pigment. Though they vary according to the microscopical subtype, these tumors often arise in the sun-exposed skin of elderly individuals, in the acral regions and in the palms and soles of the hands and feet. A 56-year-old patient visited the emergency department of our hospital with complaints of a sudden hemorrhage from a mass on her left thigh which had appeared five months ago. On physical examination a brown-black mass with dimensions of 18 x 16 x 5 cm, protruding from the skin with a partially and actively hemorrhagic, ulcerated surface, was found on the left gluteal region. The mass was excised surgically with 3 cm safe surgical margins. Histopathologically the lesion was diagnosed as "nodular malignant melanoma - Clark level 5". A malignant melanoma of such a large size is very exceptional in the literature; thus it is presented here with its interesting rapid clinical course.
恶性黑色素瘤是一种侵袭性黑素细胞肿瘤,黑素细胞的主要功能是产生黑色素。尽管这些肿瘤根据显微镜下的亚型有所不同,但它们通常发生在老年人阳光暴露的皮肤、肢端部位以及手掌和脚底。一名56岁的患者因五个月前左大腿出现的肿块突然出血而前来我院急诊科就诊。体格检查发现左臀区域有一个棕黑色肿块,大小为18×16×5cm,从皮肤突出,表面部分有活动性出血且溃疡。该肿块在手术中以3cm的安全手术切缘切除。组织病理学上,该病变被诊断为“结节性恶性黑色素瘤 - 克拉克5级”。如此大尺寸的恶性黑色素瘤在文献中非常罕见;因此,本文介绍其有趣的快速临床病程。