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1例罕见的晚期下肢恶性黑色素瘤病例

A Unique Case of Late Presentation Giant Lower Extremity Malignant Melanoma.

作者信息

Al Zarkali Omar, Marker Amanda, Kaur Lakhvir, VanDerWall Ana

机构信息

Internal Medicine, HCA Florida Blake Hospital, Bradenton, USA.

Medical Oncology, HCA Florida Blake Hospital, Bradenton, USA.

出版信息

Cureus. 2024 Mar 2;16(3):e55414. doi: 10.7759/cureus.55414. eCollection 2024 Mar.

DOI:10.7759/cureus.55414
PMID:38567210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10985282/
Abstract

This case describes a unique presentation of a rare malignancy: giant melanoma. Due to the accessibility of healthcare in the United States, it is unusual for melanomas to grow to massive sizes without clinical intervention. In fact, an in-depth literature review elicited only a handful of similar cases. Giant malignant melanomas are typically defined by a cutoff size of no less than 10 cm in diameter. They often present with distant metastases and are highly invasive. Due to limited yet highly variable presentations, there is no standardized approach to treating this class of melanomas. We present a case with unique features not previously documented in similar cases that was ultimately treated with a novel approach.

摘要

本病例描述了一种罕见恶性肿瘤——巨大黑色素瘤的独特表现。由于美国医疗保健的可及性,黑色素瘤在没有临床干预的情况下长到巨大尺寸是不常见的。事实上,深入的文献综述仅发现了少数几例类似病例。巨大恶性黑色素瘤通常定义为直径不少于10厘米。它们常伴有远处转移且具有高度侵袭性。由于表现有限且高度多变,对于这类黑色素瘤没有标准化的治疗方法。我们报告一例具有独特特征(此前类似病例中未记录过)的病例,该病例最终采用了一种新方法进行治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/47cbe5c0558e/cureus-0016-00000055414-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/596dfef669f5/cureus-0016-00000055414-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/b9e567da51de/cureus-0016-00000055414-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/ba1d18108221/cureus-0016-00000055414-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/8c224329dcde/cureus-0016-00000055414-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/8fd08427028c/cureus-0016-00000055414-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/082cdccab687/cureus-0016-00000055414-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/c522b2c74b29/cureus-0016-00000055414-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/bb32d1477782/cureus-0016-00000055414-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/47cbe5c0558e/cureus-0016-00000055414-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/596dfef669f5/cureus-0016-00000055414-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/b9e567da51de/cureus-0016-00000055414-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/ba1d18108221/cureus-0016-00000055414-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/8c224329dcde/cureus-0016-00000055414-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/8fd08427028c/cureus-0016-00000055414-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/082cdccab687/cureus-0016-00000055414-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/c522b2c74b29/cureus-0016-00000055414-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/bb32d1477782/cureus-0016-00000055414-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cba/10985282/47cbe5c0558e/cureus-0016-00000055414-i09.jpg

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本文引用的文献

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Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced -Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134.达拉非尼联合曲美替尼对比纳武利尤单抗联合伊匹木单抗治疗晚期-突变型黑色素瘤患者:DREAMseq 试验-ECOG-ACRIN EA6134。
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Unusual Presentation of Giant Upper Limb Malignant Melanoma.巨大上肢恶性黑色素瘤的罕见表现
Cureus. 2021 Aug 8;13(8):e16996. doi: 10.7759/cureus.16996. eCollection 2021 Aug.
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A case report of metastatic giant sarcomatoid melanoma with BRAF V600E mutation: a complete response to targeted therapy.
一例伴有BRAF V600E突变的转移性巨细胞肉瘤样黑色素瘤病例报告:对靶向治疗的完全缓解
Oncotarget. 2020 Aug 25;11(34):3256-3262. doi: 10.18632/oncotarget.27701.
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Association of BRAF V600E/K Mutation Status and Prior BRAF/MEK Inhibition With Pembrolizumab Outcomes in Advanced Melanoma: Pooled Analysis of 3 Clinical Trials.BRAF V600E/K 突变状态与既往 BRAF/MEK 抑制对晚期黑色素瘤患者接受 pembrolizumab 治疗结局的影响:3 项临床试验的汇总分析。
JAMA Oncol. 2020 Aug 1;6(8):1256-1264. doi: 10.1001/jamaoncol.2020.2288.
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