Medical School, Academic League of Emergency and Trauma, University of Brasilia, Brasilia, Brazil.
World J Emerg Surg. 2012 Aug 22;7 Suppl 1(Suppl 1):S10. doi: 10.1186/1749-7922-7-S1-S10.
Most trauma patients are drunk at the time of injury. Up to 2% of traumatized patients develop sepsis, which considerably increases their mortality. Inadequate wound healing of the colonic repair can lead to postoperative complications such as leakage and sepsis.
To assess the effects of acute alcohol intoxication on colonic anastomosis wound healing in septic rats.
Thirty six Wistar rats were allocated into two groups: S (induction of sepsis) and AS (alcohol intake before sepsis induction). A colonic anastomosis was performed in all groups. After 1, 3 or 7 days the animals were killed. Weight variations, mortality rate, histopathology and tensile breaking strength of the colonic anastomosis were evaluated.
There was an overall mortality of 4 animals (11.1%), three in the group AS (16.6%) and one in the S group (5.5%). Weight loss occurred in all groups. The colon anastomosis of the AS group didn't gain strength from the first to the seventh postoperative day. On the histopathological analysis there were no differences in the deposition of collagen or fibroblasts between the groups AS and S.
Alcohol intake increased the mortality rate three times in septic animals. Acute alcohol intoxication delays the acquisition of tensile strength of colonic anastomosis in septic rats. Therefore, acute alcohol intoxication before sepsis leads to worse prognosis in animal models of the abdominal trauma patients.
大多数创伤患者在受伤时都处于醉酒状态。多达 2%的创伤患者会发展为败血症，这大大增加了他们的死亡率。结肠修复的愈合不良可能导致术后并发症，如漏液和败血症。
评估急性酒精中毒对败血症大鼠结肠吻合口愈合的影响。
将 36 只 Wistar 大鼠分为两组：S 组（诱导败血症）和 AS 组（败血症前饮酒）。所有组均进行结肠吻合术。术后 1、3 或 7 天处死动物。评估体重变化、死亡率、组织病理学和结肠吻合的拉伸断裂强度。
共有 4 只动物（11.1%）死亡，AS 组 3 只（16.6%），S 组 1 只（5.5%）。所有组均出现体重减轻。AS 组的结肠吻合术在术后第 1 天至第 7 天没有增加强度。组织病理学分析显示，AS 组和 S 组之间胶原或成纤维细胞的沉积没有差异。
酒精摄入使败血症动物的死亡率增加了三倍。急性酒精中毒延迟了败血症大鼠结肠吻合口获得拉伸强度的时间。因此，在腹部创伤患者的动物模型中，败血症前的急性酒精中毒导致预后更差。
