Specialist Trainee Registrar, Sheffield Teaching Hospitals, Sheffield, United Kingdom.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Oct;116(4):e283-6. doi: 10.1016/j.oooo.2013.01.018. Epub 2013 Apr 6.
Sclerosing Odontogenic Carcinoma (SOC) was first described by Koutlas et al. in 2008. SOC is a low-grade odontogenic carcinoma, which presents as an expansile radiolucency that causes tooth displacement and root resorption. It is locally aggressive but reports suggest a very low probability of regional or distant metastasis. SOC contains small nests and thin cords of small cuboidal or polygonal epithelial cells with cytoplasmic clearing. Pleomorphism and mitoses are not prominent. Skeletal muscle and perineural infiltration with stromal sclerosis is characteristic. Immunohistochemically, SOC stains for cytokeratins (CK) 5/6 and 19, and e-cadherin. Nuclear staining with p63 is also positive. CK20, carcinoembryonic antigen and CAM 5.2 are negative. We report a rare entity of primary intraosseous carcinoma of the maxilla which has the clinical and histological markers of SOC. Occurrence in the maxilla has been reported only once before in the literature.
2008 年，Koutlas 等人首次描述了造釉细胞瘤性癌（SOC）。SOC 是一种低度牙源性癌，表现为膨胀性透光区，导致牙齿移位和牙根吸收。它具有局部侵袭性，但报告表明区域或远处转移的可能性非常低。SOC 包含小巢和薄的细索状小立方形或多边形上皮细胞，胞质透明。多形性和有丝分裂不明显。骨骼肌和神经周围浸润伴基质硬化是其特征。免疫组织化学染色显示 SOC 表达细胞角蛋白（CK）5/6 和 19，以及 E-钙黏蛋白。核 p63 染色也呈阳性。CK20、癌胚抗原和 CAM5.2 为阴性。我们报告了一例罕见的上颌骨原发性骨内癌，其具有 SOC 的临床和组织学标志物。文献中仅报道过一次上颌骨发生这种情况。
