Department of Biochemistry, Faculty of Medicine/Graduate School of Medicine, University of Yamanashi, Japan.
FEBS Lett. 2013 May 21;587(10):1453-9. doi: 10.1016/j.febslet.2013.03.030. Epub 2013 Apr 6.
Vangl is a component of the non-canonical Wnt/planar cell polarity pathway, which is implicated in various cell polarity functions. However, little is known about its synaptic localization in neurons. Here, we show that Vangl1 and Vangl2 are expressed in adult rat neurons, where they are tightly associated with the postsynaptic density (PSD) fraction. Vangl2 forms a complex with PSD-95 through direct binding. Furthermore, the C-terminal PDZ-binding motif of Vangl2 is required for localization to dendritic spines. These results suggest that Vangl2 is a new component of the PSD that forms a complex with PSD-95 in the adult brain.
Vangl 是非经典 Wnt/平面细胞极性途径的一个组成部分，该途径涉及各种细胞极性功能。然而，关于其在神经元中的突触定位知之甚少。在这里，我们表明 Vangl1 和 Vangl2 在成年大鼠神经元中表达，在那里它们与突触后密度 (PSD) 部分紧密相关。Vangl2 通过直接结合与 PSD-95 形成复合物。此外，Vangl2 的 C 端 PDZ 结合基序对于定位于树突棘是必需的。这些结果表明 Vangl2 是 PSD 的一个新成分，它在成年大脑中与 PSD-95 形成复合物。
