平面细胞极性跨膜蛋白Vangl2促进哺乳动物前脑树突、棘突和谷氨酸能突触的形成。
The Planar Cell Polarity Transmembrane Protein Vangl2 Promotes Dendrite, Spine and Glutamatergic Synapse Formation in the Mammalian Forebrain.
作者信息
Okerlund Nathan D, Stanley Robert E, Cheyette Benjamin N R
机构信息
Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, Calif., USA; Department of Psychiatry, Stanford University, Palo Alto, Calif., USA.
Department of Psychiatry, Stanford University, Palo Alto, Calif., USA; Tetrad Graduate Program, Stanford University, Palo Alto, Calif., USA.
出版信息
Mol Neuropsychiatry. 2016 Jul;2(2):107-14. doi: 10.1159/000446778. Epub 2016 Jun 24.
The transmembrane protein Vangl2, a key regulator of the Wnt/planar cell polarity (PCP) pathway, is involved in dendrite arbor elaboration, dendritic spine formation and glutamatergic synapse formation in mammalian central nervous system neurons. Cultured forebrain neurons from Vangl2 knockout mice have simpler dendrite arbors, fewer total spines, less mature spines and fewer glutamatergic synapse inputs on their dendrites than control neurons. Neurons from mice heterozygous for a semidominant Vangl2 mutation have similar but not identical phenotypes, and these phenotypes are also observed in Golgi-stained brain tissue from adult mutant mice. Given increasing evidence linking psychiatric pathophysiology to these subneuronal sites and structures, our findings underscore the relevance of core PCP proteins including Vangl2 to the underlying biology of major mental illnesses and their treatment.
跨膜蛋白Vangl2是Wnt/平面细胞极性（PCP）通路的关键调节因子，参与哺乳动物中枢神经系统神经元的树突分支细化、树突棘形成和谷氨酸能突触形成。与对照神经元相比，来自Vangl2基因敲除小鼠的培养前脑神经元具有更简单的树突分支、更少的总棘突、不太成熟的棘突以及其树突上更少的谷氨酸能突触输入。携带半显性Vangl2突变的杂合小鼠的神经元具有相似但不完全相同的表型，并且在成年突变小鼠的高尔基染色脑组织中也观察到这些表型。鉴于越来越多的证据将精神病理生理学与这些亚神经元位点和结构联系起来，我们的研究结果强调了包括Vangl2在内的核心PCP蛋白与主要精神疾病的潜在生物学及其治疗的相关性。
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