Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
J Immunol. 2013 May 15;190(10):4923-7. doi: 10.4049/jimmunol.1300350. Epub 2013 Apr 8.
We demonstrated recently that, after accumulation of Ag-engaged B cells at the T cell zone boundaries in the spleen, these B cells migrate to the perimeter of follicles adjacent to the marginal zone. They undergo rapid proliferation at this site prior to coalescence into germinal centers (GCs). In this article, we report that this phase of migration and expansion of activated Ag-specific B cells, as well as subsequent formation of GCs, does not take place in the absence of splenic macrophages. Our data suggest a previously unappreciated function for macrophages in orchestrating the early phases of T cell-dependent B cell responses and formation of GCs distinct from their potential role in Ag presentation to T cells.
我们最近证明，在 Ag 结合的 B 细胞在脾脏的 T 细胞区边界处积累之后，这些 B 细胞迁移到邻近边缘区的滤泡的周边。在这个部位，它们在融合形成生发中心（GC）之前迅速增殖。在本文中，我们报告说，这种活化的 Ag 特异性 B 细胞的迁移和扩增阶段，以及随后 GC 的形成，如果没有脾脏巨噬细胞就不会发生。我们的数据表明，巨噬细胞在协调 T 细胞依赖性 B 细胞反应的早期阶段和形成不同于其向 T 细胞呈递 Ag 的潜在作用的 GC 方面具有以前未被认识到的功能。
