Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
J Immunol. 2012 Jun 1;188(11):5389-96. doi: 10.4049/jimmunol.1102808. Epub 2012 Apr 23.
The signals required to generate long-lived plasma cells remain unresolved. One widely cited model posits that long-lived plasma cells derive from germinal centers (GCs) in response to T cell-dependent (TD) Ags. Thus, T cell-independent (TI) Ags, which fail to sustain GCs, are considered ineffective at generating long-lived plasma cells. However, we show that long-lived hapten-specific plasma cells are readily induced without formation of GCs. Long-lived plasma cells developed in T cell-deficient mice after a single immunization with haptenated LPS, a widely used TI Ag. Long-lived plasma cells also formed in response to TD Ag when the GC response was experimentally prevented. These observations establish that long-lived plasma cells are induced in both TI and TD responses, and can arise independently of B cell maturation in GCs.
产生长寿浆细胞所需的信号仍未解决。一个被广泛引用的模型假设，长寿浆细胞来源于生发中心（GC），以响应 T 细胞依赖性（TD）抗原。因此，不能维持 GC 的 T 细胞非依赖性（TI）抗原被认为在产生长寿浆细胞方面无效。然而，我们表明，在单次免疫结合半抗原的脂多糖（一种广泛使用的 TI 抗原）后，即使没有 GC 的形成，也可以很容易地诱导产生长寿的半抗原特异性浆细胞。在 T 细胞缺陷小鼠中，当实验性地阻止 GC 反应时，也会产生长寿的浆细胞。这些观察结果表明，在 TI 和 TD 反应中都诱导了长寿浆细胞，并且可以独立于 GC 中 B 细胞的成熟而产生。
