University of Bremen, Advanced Ceramics, Am Biologischen Garten 2, 28359 Bremen, Germany.
Acta Biomater. 2013 Jul;9(7):7115-50. doi: 10.1016/j.actbio.2013.03.036. Epub 2013 Apr 6.
Surface functionalization has become of paramount importance and is considered a fundamental tool for the development and design of countless devices and engineered systems for key technological areas in biomedical, biotechnological and environmental applications. In this review, surface functionalization strategies for alumina, zirconia, titania, silica, iron oxide and calcium phosphate are presented and discussed. These materials have become particularly important concerning the aforementioned applications, being not only of great academic, but also of steadily increasing human and commercial, interest. In this review, special emphasis is given to their use as biomaterials, biosensors, biological targets, drug delivery systems, implants, chromatographic supports for biomolecule purification and analysis, and adsorbents for toxic substances and pollutants. The objective of this review is to provide a broad picture of the enormous possibilities offered by surface functionalization and to identify particular challenges regarding surface analysis and characterization.
表面功能化已变得至关重要，被视为生物医学、生物技术和环境应用等关键技术领域无数设备和工程系统的开发和设计的基本工具。在这篇综述中，介绍并讨论了氧化铝、氧化锆、二氧化钛、二氧化硅、氧化铁和磷酸钙的表面功能化策略。这些材料在上述应用中变得尤为重要，不仅具有重要的学术意义，而且越来越受到人类和商业的关注。在这篇综述中，特别强调了它们作为生物材料、生物传感器、生物靶标、药物输送系统、植入物、生物分子纯化和分析的色谱支持物以及有毒物质和污染物的吸附剂的用途。本文的目的是提供表面功能化所提供的巨大可能性的广泛概述，并确定表面分析和表征方面的特定挑战。
