National TCM Key Lab of Serum Pharmacochemistry, Key Lab of Chinmedomics, Key Pharmacometabolomics Platform of Chinese Medicines, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China.
Eur J Med Chem. 2013 May;63:570-7. doi: 10.1016/j.ejmech.2012.12.062. Epub 2013 Mar 4.
Liver disease is any condition that may cause liver inflammation or tissue damage and affects liver function. Natural products that are found in vegetables, fruits, plant extracts, herbs, insects, and animals, have been traditionally used for treating liver diseases. They are chemical compounds that usually have biological activities for use in drug discovery and design. Many natural products have been clinically available as potent hepatoprotective agents against commonly occurring liver diseases. This review summarizes the current progress in the basic, clinical, and translational research on natural products in treatment of various liver diseases. Furthermore, we will focus on the discovery and biological evaluation of the natural products, which shows potential as a new therapeutic agent of liver diseases.
肝脏疾病是指任何可能导致肝脏炎症或组织损伤并影响肝脏功能的疾病。蔬菜、水果、植物提取物、草药、昆虫和动物中存在的天然产物，一直以来都被用于治疗肝脏疾病。它们是通常具有生物活性的化合物，可用于药物发现和设计。许多天然产物已在临床上作为有效的肝保护剂用于治疗常见的肝脏疾病。本综述总结了天然产物在治疗各种肝脏疾病方面的基础、临床和转化研究的最新进展。此外，我们将重点介绍天然产物的发现和生物学评估，这些天然产物显示出作为肝脏疾病治疗新方法的潜力。
